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Design, Synthesis, and Biological Evaluation of Novel 2-(4-Arylsubstituted-1H,2,3-triazol-1-yl)-N-{4-[2-(thiazol-2-yl)benzo[d]thiazol-6-yl]phenyl}acetamide Derivatives as Potent Anticancer Agents

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Abstract

A novel series of benzothiazole bearing 1,2,3-triazole derivatives 11a–11j are synthesized, and their structures are confirmed by 1H and 13C NMR, and mass spectral data. The synthesized compounds are tested for their anticancer activity towards human cancer cell lines including MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian) and demonstrate moderate to high activity. Among those, compounds 11b, 11c, 11d, 11e, 11f, and 11g are characterized by more potent activity than the standard drug.

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Authors and Affiliations

  1. Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Andhra Pradesh, 522510, India

    Y. J. Pragathi, D. Veronica, S. Madhavi & R. R. Raju

  2. Department of Chemistry, University College of Engineering (Autonomous), Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh, 533003, India

    R. Sreenivasulu

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  1. Y. J. Pragathi
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  2. R. Sreenivasulu
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  3. D. Veronica
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  4. S. Madhavi
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  5. R. R. Raju
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Correspondence to R. R. Raju.

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Pragathi, Y.J., Sreenivasulu, R., Veronica, D. et al. Design, Synthesis, and Biological Evaluation of Novel 2-(4-Arylsubstituted-1H,2,3-triazol-1-yl)-N-{4-[2-(thiazol-2-yl)benzo[d]thiazol-6-yl]phenyl}acetamide Derivatives as Potent Anticancer Agents. Russ J Gen Chem 89, 1009–1014 (2019). https://doi.org/10.1134/S1070363219050220

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  • DOI: https://doi.org/10.1134/S1070363219050220

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