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Design, Synthesis, and Anticancer Activity of Novel 2-(4-Arylsubstituted-1H-1,2,3-triazol-1-yl)-N-{4-[2-(thiazol-2-yl)benzo[d]thiazol-6-yl]phenyl}acetamide Derivatives

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Abstract

A number of novel benzothiazole derivatives bearing 1,2,3-triazole has been synthesized. Molecular structures of the products are confirmed by 1H and 13C NMR, and mass spectral data. Anticancer activity of the products has been tested against human cancer cell lines: MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian). The synthesized compounds have demonstrated high to moderate activity. Six of those have been characterized by higher activity than that of the standard drug.

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Authors and Affiliations

  1. Department of Chemistry, JNT University, Hyderabad, 500082, Telangana, India

    R. Polothi & K. Sheelam

  2. GVK Biosciences Private Limited, Nacharam, IDA Mallapur, Hyderabad, 500076, Telangana, India

    R. Polothi, G. S. B. Raolji & K. Sheelam

  3. Department of Chemistry, Krishna University, Machilipatnam, 521001, Andhra Pradesh, India

    M. V. B. Rao

  4. C.M.R. College of Pharmacy, Medchal, Hyderabad, 501401, Telangana, India

    V. Sastry K

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  1. R. Polothi
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  2. G. S. B. Raolji
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Correspondence to R. Polothi.

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Polothi, R., Raolji, G.S.B., Rao, M.V.B. et al. Design, Synthesis, and Anticancer Activity of Novel 2-(4-Arylsubstituted-1H-1,2,3-triazol-1-yl)-N-{4-[2-(thiazol-2-yl)benzo[d]thiazol-6-yl]phenyl}acetamide Derivatives. Russ J Gen Chem 90, 2509–2513 (2020). https://doi.org/10.1134/S1070363220120452

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