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Synthesis, Crystal Structure, and Anticancer Activity of the Dinuclear Dibutyltin Complexes

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Abstract

Dinuclear dibutyltin complexes {[2-O-C6H4(O)C=N-N=C(O)CPh2O](n-Bu2Sn)2}n (C1) and {[2-(3-O-C8H6)(O)C=N-N=C-2-(3-O-C8H6)]2(n-Bu2Sn)2}n (C2) have been synthesized and characterized by IR, 1H, 13C, and 119Sn NMR spectra, HRMS, elemental analysis, and thermal stability analysis. Their crystal structures have been determined by X-ray diffraction. In vitro antitumor activities of both complexes have been evaluated by the CCK8 method against three human cancer cell lines (MCF-7, NCI-H460, and HepG2), and the complexes have exhibited high activity against MCF-7 and HepG2.

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Funding

This work was supported by the 22nd College students Extracurricular Academic Science and Technology Works Competition Project of Hengyang Normal University (no. 13).

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Authors and Affiliations

  1. Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, Hunan Provincial Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of XiangJiang River, College of Chemistry and Materials Science, Hengyang Normal University, Hengyang, 421008, Hunan, China

    Aodian Li, Tiantian Wang, Yunyun Feng, Qiqi Qin, Wujiu Jiang & Yuxing Tan

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  1. Aodian Li
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Correspondence to Wujiu Jiang or Yuxing Tan.

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Li, A., Wang, T., Feng, Y. et al. Synthesis, Crystal Structure, and Anticancer Activity of the Dinuclear Dibutyltin Complexes. Russ J Gen Chem 92, 908–913 (2022). https://doi.org/10.1134/S1070363222050218

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