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Syntheses, Crystal Structures and Biological Activity of the 1D Chain Benzyltin Complexes Based on 2-Oxo-Propionic Acid Benzoyl Hydrazone

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Abstract

Two new 1D Chain benzyltin complexes {[C6H4(O)C=N–N=C(Me)COO](CH3OH)(C6H5CH2)2Sn}n (1), {[C6H4(O)C–NH–N=C(Me)COO](C6H5CH2)3Sn}n (2) were synthesized by the reactions of 2-oxo-propionic acid benzoyl hydrazone with dibenzyltin dichloride or tribenzyltin chloride, respectively. The two complexes were characterized by FT-IR, 1H, 13C and 119Sn NMR spectra, elemental analysis, X-ray single crystal diffraction and TGA. In vitro antitumor activities of both complexes were evaluated by the 3-(4,5-dimethylthiazoly-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against three human cancer cell lines (NCI-H460, HepG2, MCF7) and human cell line (HL7702). The 1 exhibited strong antitumor activity than 2, then it was expected after further chemical optimization of candidate compounds as anti-cancer drugs. The interaction between complexes and calf thymus DNA were studied by EB fluorescent probe, the interaction of 1 and 2 with calf thymus DNA were intercalation and electrostatic attraction.

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Acknowledgements

The project was supported by the Scientific and Technological Projects of Hunan Province of China (No. 2015JC3060), Hunan Provincial Natural Science Foundation of China (No. 2016JJ4008) and The Innovation Platform Open Fund Project of Hunan Provincial Education Department of China (No. 16K011).

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Authors and Affiliations

  1. Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan, 421008, China

    Yu-Xing Tan, Zhi-Jian Zhang, Yong-Lan Feng, Jiang-Xi Yu, Xiao-Ming Zhu, Fu-Xing Zhang, Dai-Zhi Kuang & Wu-Jiu Jiang

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Tan, YX., Zhang, ZJ., Feng, YL. et al. Syntheses, Crystal Structures and Biological Activity of the 1D Chain Benzyltin Complexes Based on 2-Oxo-Propionic Acid Benzoyl Hydrazone. J Inorg Organomet Polym 27, 342–352 (2017). https://doi.org/10.1007/s10904-016-0477-5

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