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Design, Synthesis, and Biological Evaluation of 1,2,4-Oxadiazole-Isoxazole Linked Quinazoline Derivatives as Anticancer Agents

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Abstract

A series of novel 1,2,4-oxadiazole-isoxazole linked quinazoline compounds is designed, synthesized and screened for anticancer activity on four human cancer cell lines including MCF-7 (breast), A549 (lung), DU-145 (prostate), and MDA MB-231 (breast) by using MTT assay with etoposide used as a positive reference. All compounds demonstrate good to moderate anticancer activity and two compounds are found to be the most potent.

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Authors and Affiliations

  1. Department of Chemistry, Kakinada, 533003, India

    M. Srinivas & S. Satyaveni

  2. Green Evolution Laboratories, Wangapally Village, Nalgonda, AP, 508286, India

    B. Ram

Authors
  1. M. Srinivas
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  2. S. Satyaveni
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  3. B. Ram
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Correspondence to S. Satyaveni.

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Srinivas, M., Satyaveni, S. & Ram, B. Design, Synthesis, and Biological Evaluation of 1,2,4-Oxadiazole-Isoxazole Linked Quinazoline Derivatives as Anticancer Agents. Russ J Gen Chem 89, 2492–2497 (2019). https://doi.org/10.1134/S1070363219120260

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  • DOI: https://doi.org/10.1134/S1070363219120260

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