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Synthesis, Characterization, Computational, Antimicrobial Screening, and MTT Assay of Thiazolidinone Derivatives Containing the Indole and Pyridine Moieties

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Abstract

A series of novel 2-{[1-(arenesulfonyl)-1H-indol-3-yl]-4-oxo-1,3-thiazolidin-3-yl}pyridine-4-carboxamide derivatives was designed and calculate for their computational properties like physicochemical parameters and bioactivity score. Bioactive compounds 1–8, were then synthesized, Characterized by various spercoscopic techniques and assessed for antibacterial activity against S. aureus, S. epidermidis, P. mirabilis, and E. coli. The percent viability of the cells was carried out by MTT assay using HepG2 cells. The results for antibacterial activity were observed in strong recommendation with the computation results. The synthesized compounds were found to portray better activity and lower cytotoxicity when compared to the standard drug Ciprofloxacin.

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Authors and Affiliations

  1. Department of Basic Sciences, College of Medicine, Al Dawadmi, Shaqra University, 11911, Shaqra, Saudi Arabia

    M. Arshad

  2. Interdisciplinary Nanotechnology Centre, Aligarh Muslim University, Aligarh, India

    M. Shoeb Khan

  3. Department of Kulliyat, Faculty of Unani Medicine, Aligarh Muslim University, Aligarh, India

    S. A. Asghar Nami

  4. College of Pharmacy, Al-Dawadmi, Shaqra University, Shaqra, Saudi Arabia

    D. Ahmad

Authors
  1. M. Arshad
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  2. M. Shoeb Khan
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  3. S. A. Asghar Nami
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  4. D. Ahmad
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Correspondence to M. Arshad.

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Arshad, M., Shoeb Khan, M., Asghar Nami, S.A. et al. Synthesis, Characterization, Computational, Antimicrobial Screening, and MTT Assay of Thiazolidinone Derivatives Containing the Indole and Pyridine Moieties. Russ J Gen Chem 88, 2154–2162 (2018). https://doi.org/10.1134/S1070363218100213

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  • DOI: https://doi.org/10.1134/S1070363218100213

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