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Novel method of 4,6-dimethyl-2-thioxo-1,2-dihydronicotinonitrile synthesis

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Abstract

Condensation of acetaldehyde with cyanothioacetamide and 1-(prop-1-en-2-yl)pyrrolidine has afforded 4,6-dimethyl-2-thioxo-1,2-dihydronicotinonitrile. Alkylation of the latter with α-haloketones yields substituted 2-alkylsulfanyl-4,6-dimethylnicotinonitriles and thieno[2,3-b]pyridines.

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Authors and Affiliations

  1. Shevchenko Lugansk University, ul. Oboronnyaya 2, Lugansk, 91011, Ukraine

    I. V. Dyachenko

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  1. I. V. Dyachenko
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Correspondence to I. V. Dyachenko.

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Original Russian Text © I.V. Dyachenko, 2015, published in Zhurnal Obshchei Khimii, 2015, Vol. 85, No. 8, pp. 1276–1279.

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Dyachenko, I.V. Novel method of 4,6-dimethyl-2-thioxo-1,2-dihydronicotinonitrile synthesis. Russ J Gen Chem 85, 1834–1837 (2015). https://doi.org/10.1134/S1070363215080083

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  • DOI: https://doi.org/10.1134/S1070363215080083

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