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Synthesis and Anti-Microbial Activity of Benzylidenhydrazides of Glycyrrethic Acid

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Abstract

New derivatives of glycyrrhetic acid with hydrazide pharmacophore groups were synthesized and their antimicrobial activity was evaluated. Hydrazide of 3-O-acetyl-N'-(4-hydroxybenzylidene) glycyrrhetic acid exhibited the highest antimicrobial activity. This compound had both an antibacterial effect against Escherichia coli, Proteus vulgaris, Klebsiella pneumonia, Staphylococcus aureus, Citrobacter diversus, Enterobacter aerogenes, Pseudomonas aeruginosa, and Enterobacter cloacae and antifungal activity against the Candida albicans fungus. The minimum inhibitory concentrations of this compound and pimafucin were similar for Candida albicans.

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Funding

This study was performed within the framework of project no. АААА-А17-11701191025-6 with the use of the equipment of TsPK Khimiya.

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Ufa Federal Science Center, Russian Academy of Sciences, 450054, Ufa, Russia

    L. A. Baltina

  2. Bashkir State Medical University of the Russian Ministry of Health, 450000, Ufa, Russia

    R. M. Kondratenko & A. K. Bulgakov

Authors
  1. L. A. Baltina
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  2. R. M. Kondratenko
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  3. A. K. Bulgakov
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Corresponding author

Correspondence to L. A. Baltina.

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COMPLIANCE WITH ETHICAL STANDARDS

This article does not contain any studies involving human participants and animals performed by any of the authors.

Conflict of Interests

The authors declare that they have no conflicts of interest.

Additional information

Translated by L. Onoprienko

Abbreviations: GLA, glycyrrhetic acid; BEB, beef-extract broth; MIC, minimum inhibiting concentration.

Corresponding author: phone: +7 (917) 424-68-12; e-mail: baltina@anrb.ru.

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Baltina, L.A., Kondratenko, R.M. & Bulgakov, A.K. Synthesis and Anti-Microbial Activity of Benzylidenhydrazides of Glycyrrethic Acid. Russ J Bioorg Chem 46, 246–251 (2020). https://doi.org/10.1134/S1068162020020065

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  • DOI: https://doi.org/10.1134/S1068162020020065

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