Skip to main content
SpringerLink
Log in

Isolation of 117mSn from Proton-irradiated Titanium–Antimony Intermetallic Compound

  • Published:
Radiochemistry Aims and scope

Abstract

Various methods have been developed for the extraction of a promising medical radionuclide 117mSn from proton-irradiated TiSb intermetallic compound, a target material suitable for irradiation with an intense beam of accelerated protons. To separate radiotin from Ti, Sb, and radionuclides of other elements, methods of ion-exchange chromatography and liquid extraction were used, in particular, the anion-exchange separation of tin and titanium in the form of a peroxide complex in HCl solution, extraction of tin with benzene from iodide solutions, and chromatographic purification on silica gel from citrate solutions. As a result, 117mSn of high purity, which meets the requirements for nuclear medicine, was obtained.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.
Fig. 5.
Fig. 6.
Fig. 7.
Fig. 8.
Fig. 9.
Fig. 10.

Similar content being viewed by others

REFERENCES

  1. Srivastava, S.C., Postgrad. Med. Edu. Res., 2013, vol. 47, p. 31.

    Article  Google Scholar 

  2. Mausner, L.F., Mirzadeh, S., and Srivastava, S.C., Appl. Radiat. Isot., 1992, vol. 43, no. 9, p. 1117.

    Article  CAS  Google Scholar 

  3. Srivastava, S.C., Atkins, H.L., Krishnamurthy, G.T., Zanzi, I., Silberstein, E.B., Meinken, G., Mausner, L.F., Swailem, F., D’Alessandro, T., Cabahug, C.J., Lau, Y., Park, T., and Madajewicz, S., Clin. Cancer Res., 1998, vol. 4, p. 61.

    CAS  PubMed  Google Scholar 

  4. Gerbail, T., J. Nucl. Med., 1997, vol. 38, no. 2, p. 230.

    Google Scholar 

  5. Atkins, H.L., Mausner, L.F., Srivastava, S.C., Meinken, G.E., Cabahug, C.J., and D’Alessandro, T., J. Nucl. Med., 1995, vol. 36, no. 5, p. 725.

    CAS  PubMed  Google Scholar 

  6. Stevenson, N.R., Radiother. Oncol., 2016, vol. 118, p. S97.

    Article  Google Scholar 

  7. Toporov, Y.G., Andreyev, O.I., Vakhetov, F.Z., Gavrilov, V.D., and Shrivastava, S.C., Abstracts of Papers, 9th Int. Symp. on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds, July 16-20, 2006 , Edinburgh (UK), 2006, p. 64.

  8. Mausner, L.F., Kolsky, K.L., Joshi, V., and Srivastava, S.C., Appl. Radiat. Isot., 1998, vol. 49, p. 285.

    Article  CAS  Google Scholar 

  9. Ermolaev, S.V., Zhuikov, B.L., Kokhanyuk, V.M., and Srivastava, S.C., J. Label. Compd. Radiopharm., 2007, vol. 50, p. 611.

    Article  CAS  Google Scholar 

  10. Qaim, S.M., and Döhler, H., Appl. Radiat. Isot., 1984, vol. 35, p. 645.

    Article  CAS  Google Scholar 

  11. Stevenson, N.R., George, G.S., Simón, J., Srivastava, S.C., Mueller, D.W., Gonzales, G.R., Roger, J.A., Frank, R.K., and Horn, I.M., J. Radioanal. Nucl. Chem., 2015, vol. 305, p. 99.

    Article  CAS  Google Scholar 

  12. Haddad, F., Barbet, J., and Chatal, J.F., Curr. Radiopharm., 2011, vol. 4, p. 186.

    Article  CAS  Google Scholar 

  13. Kiselev, M., Lambert, B., Richards, V., Skarupa, W., Wardach, M., Zehner J., Ermolaev S., and Zhuikov, B., Abstracts of Papers, 9th Int. Conf. on Isotopes, Doha (Qatar), Nov. 12–16, 2017, p. 5.

  14. Ermolaev, S.V., Zhuikov, B.L., Kokhanyuk, V.M., Matushko, V.L., and Srivastava, S.C., Radiochim. Acta, 2020, vol. 108, p. 327.

    Article  CAS  Google Scholar 

  15. Ermolaev, S.V., Zhuikov, B.L., Kokhanyuk, V.M., Abramov, A.A., Togaeva, N.R., Khamianov, S.V., and Srivastava, S.C., J. Radioanal. Nucl. Chem., 2009, vol. 280, no. 2, p. 319.

    Article  CAS  Google Scholar 

  16. Patent RU2403639, publ. 2008; Patent US8449816 B2, publ. 2008.

  17. Nowotny, H.J., Monatsh. Chem., 1951, vol. 82, p. 336.

    Article  CAS  Google Scholar 

  18. Miedema, A.R., and Philips, N.V., J. Less-Common Met., 1976, vol. 46, p. 67.

    Article  CAS  Google Scholar 

  19. Doll, W., and Specker, H.Z., Anal. Chem., 1958, vol. 161, p. 354.

    Article  CAS  Google Scholar 

  20. Kono, T., Jpn. Analyst, 1971, vol. 20, p. 552.

    Article  CAS  Google Scholar 

  21. Leblond, A.M., and Boulin, R., Chim. Anal., 1968, vol. 50, no. 4, p. 171.

    CAS  Google Scholar 

  22. Tanaka, K., Jpn. Analyst., 1964, vol.1, p. 725.

    Article  Google Scholar 

  23. Kuroda, R., Oguma, K., Kono, N., and Takahashi, Y., Anal. Chim. Acta, 1972, vol. 62, p. 343.

  24. Strelow, F.W., Anal. Chem., 1963, vol. 35, p. 1279.

    Article  CAS  Google Scholar 

  25. Strelow, F.W., and Bothma, C.J., Anal. Chem., 1967, vol. 39, p. 595.

    Article  CAS  Google Scholar 

  26. Patent RU2393564, publ. 2008; Patent US8290110, publ. 2009.

  27. Zhuikov, B.L., Kokhanyuk, V.M., Konyakhin, N.A., and Vincent, J., Nucl. Instrum. Meth. Phys. Res., Sect. A., 1999, vol. 438, p. 173.

    Article  CAS  Google Scholar 

  28. National Nuclear Data Center, Brookhaven National Laboratory, USA. http://www.nndc.bnl.gov/nudat2/.

  29. Ponomarev, A.I., Metody khimicheskogo analiza zheleznykh, titanomagnetitovykh i khromovykh rud (Methods of Chemical Analysis of Iron, Titanomagnetite, and Chromium Ores), Moscow: Nauka, 1966.

    Google Scholar 

  30. Patent RU2398296, publ. 2008; Patent US8097064, publ. 2012.

Download references

ACKNOWLEDGMENTS

The study was carried out using the equipment of the Center for Collective Use “Accelerator Center for Neutron Research of the Structure of Matter and Nuclear Medicine, INR RAS”.

The authors are especially grateful to Prof. Suresh Srivastava of Brookhaven National Laboratory (USA) for initiating this work and important recommendations. The authors are also grateful to N.R. Togaeva (A.I. Leipunsky Institute of Physics and Power Engineering) for help in this study, as well as A.N. Vasiliev (INR RAS) for useful discussions.

Funding

The study was supported by the US Department of Energy’s Initiative for Proliferation Prevention Program # BNL-T2-324.

Author information

Authors and Affiliations

  1. Institute for Nuclear Research of the Russian Academy of Sciences, 117312, Moscow, Russia

    E. V. Lapshina, S. V. Ermolaev & B. L. Zhuikov

Authors
  1. E. V. Lapshina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. V. Ermolaev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. L. Zhuikov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E. V. Lapshina.

Ethics declarations

The authors declare that the have no conflict of interest.

Additional information

Translated from Radiokhimiya, No. 6, pp. 559–571, December, 2021 https://doi.org/10.31857/S0033831121060083

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lapshina, E.V., Ermolaev, S.V. & Zhuikov, B.L. Isolation of 117mSn from Proton-irradiated Titanium–Antimony Intermetallic Compound. Radiochemistry 63, 788–800 (2021). https://doi.org/10.1134/S1066362221060114

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1066362221060114

Keywords:

Search

Navigation