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Synthesis and Preliminary Biological Evaluation of 99mTc Tricarbonyl Ropinirole as a Potential Brain Imaging Agent

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Abstract

Ropinirole, a non-ergoline dopamine agonist, was labeled with 99mTc tricarbonyl {[99mTc(CO)3·(H2O)3]+} with the aim of obtaining a new brain imaging agent. For in vivo use, the radiosynthesis of 99mTc tricarbonyl ropinirole was performed by heating a solution containing ropinirole and the precursor, 99mTc tricarbonyl, on a boiling water bath for 30 min. The influence of the substrate amount and pH on the reaction was studied to optimize the synthesis. The biodistribution and scintigraphic studies demonstrate the suitability of 99mTc tricarbonyl ropinirole as a novel tracer for brain tumor imaging.

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References

  1. Kakouris, A., Samara, V., Kalaskani, A., and Panderi, I., Chromatographia, 2014, vol. 77, no. 5, pp. 447–457.

    Article  CAS  Google Scholar 

  2. Jost, W.H. and Angersbach, D., Drug Rev., 2005, vol. 11, pp. 253–272.

    Article  CAS  Google Scholar 

  3. Matheson A.J. and Spencer, C.M., Drugs, 2000, vol. 60, pp. 115–137.

    Article  CAS  Google Scholar 

  4. Maratos, E.C., Jackson, M.J., Pearce, R.K.B., and Jenner, P., Movement Disorders, 2001, vol. 16, pp. 631–641.

    Article  CAS  Google Scholar 

  5. Kushida, C.A., Neuropsych. Disease Treat., 2006, vol. 2, pp. 407–419.

    Article  CAS  Google Scholar 

  6. Farid, K., Petras, S., Ducasse, V., et al., Nucl. Med. Commun., 2012, vol. 33, pp. 571–580.

    Article  Google Scholar 

  7. Bateman, T.M., J. Nucl. Cardiol., 2012, vol. 19, suppl. 1, pp. 3–11.

    Article  Google Scholar 

  8. Alberto, R., Schibli, R., Egli, A., et al., J. Am. Chem. Soc., 1998, vol. 120, pp. 7987–7988.

    Article  CAS  Google Scholar 

  9. Reznick, R.K., Dawson-Saunders, E., and Folse, J.R., Surgery, 1987, vol. 101, p. 611.

    CAS  PubMed  Google Scholar 

  10. Cheatham, M.L., Am. Surg., 2000, vol. 66, p. 585.

    CAS  PubMed  Google Scholar 

  11. Emerson, J.D. and Colditz G.A., New Engl. J. Med., 1983, vol. 309, p. 709.

    Article  CAS  Google Scholar 

  12. Sanad, M.H., Marzook, E.A., and El-Kawy, O.A., Radiochemistry, 2017, vol. 59, no. 6, pp. 624–629.

    Article  CAS  Google Scholar 

  13. Sanad, M.H., El-Bayoumy A.S.A., and Ibrahim, A.A., J. Radioanal. Nucl. Chem., 2017, vol. 311, no. 1, pp. 1–14.

    Article  CAS  Google Scholar 

  14. Sanad, M.H., Salama, D.H., and Marzook, F.A., Radiochim. Acta, 2017, vol. 105, no. 5, pp. 389–398.

    Article  CAS  Google Scholar 

  15. Neirinckx, R.D., Canning, L.R., Piper, I.M., et al., J. Nucl. Med., 1987, vol. 28, pp. 191–202.

    CAS  PubMed  Google Scholar 

  16. Walovitch, R.C., Hill, T.C., Garrity, S.T., et al, J. Nucl. Med., 1989, vol. 30, no. 11, pp. 1892–1901.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Labeled Compounds Department, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

    M. H. Sanad

  2. Department of Chemistry, Government College University, Faisalabad, Pakistan

    F. A. Rizvi

  3. Centre for Nuclear Medicine, Panjab University, Chandigarh, India

    R. R. Kumar

  4. Applied Organic Chemistry Deptartment, Organic Chemical Industries Division, National Research Center, P.O. Box 12622, Cairo, Egypt

    A. A. Ibrahim

Authors
  1. M. H. Sanad
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  2. F. A. Rizvi
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  3. R. R. Kumar
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  4. A. A. Ibrahim
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Corresponding author

Correspondence to F. A. Rizvi.

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The authors declare that they have no conflict of interest.

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Sanad, M.H., Rizvi, F.A., Kumar, R.R. et al. Synthesis and Preliminary Biological Evaluation of 99mTc Tricarbonyl Ropinirole as a Potential Brain Imaging Agent. Radiochemistry 61, 754–758 (2019). https://doi.org/10.1134/S1066362219060195

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  • DOI: https://doi.org/10.1134/S1066362219060195

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