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Modification of an Anion-Exchange Procedure for 68Ga Preconcentration and Automated Synthesis of [68Ga]Ga-PSMA-11

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Abstract

An anion-exchange procedure for concentrating 68Ga produced from a 68Ga/68Ge generator (Cyclotron Company, Russia) was studied systematically. The procedure for preparing [68Ga]Ga-PSMA-11 of the quality meeting all the requirements for clinical use in a high yield (58 ± 3% or the activity eluted from the generator, n = 10) was developed. Synthesis of [68Ga]Ga-PSMA-11 was performed on an automated unit designed at the Almazov National Medical Research Centre.

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Acknowledgments

The authors are grateful to Khlopin Radium Institute staff members S.A. Rodionov and B.K. Kudelin for invaluable assistance in analysis of the solutions for the 68Ge content.

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Authors and Affiliations

  1. Almazov National Medical Research Centre, Ministry of Public Health of the Russian Federation, ul. Akkuratova 2, St. Petersburg, 197341, Russia

    D. O. Antuganov, D. V. Ryzhkova, V. V. Timofeev, T. A. Zykova, Yu. O. Antuganova, K. Yu. Timofeeva, O. P. Samburov & M. P. Zykov

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  1. D. O. Antuganov
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  2. D. V. Ryzhkova
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  3. V. V. Timofeev
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  4. T. A. Zykova
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  5. Yu. O. Antuganova
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  6. K. Yu. Timofeeva
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  7. O. P. Samburov
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  8. M. P. Zykov
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Correspondence to M. P. Zykov.

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The authors declare that they have no conflict of interest.

Russian Text © The Author(s), 2019, published in Radiokhimiya, 2019, Vol. 61, No. 6, pp. 523–528.

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Antuganov, D.O., Ryzhkova, D.V., Timofeev, V.V. et al. Modification of an Anion-Exchange Procedure for 68Ga Preconcentration and Automated Synthesis of [68Ga]Ga-PSMA-11. Radiochemistry 61, 748–753 (2019). https://doi.org/10.1134/S1066362219060183

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  • DOI: https://doi.org/10.1134/S1066362219060183

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