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Preparation of 188Re-Labetalol as a β1-Adrenoceptor for Use in Nuclear Medicine

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Radiochemistry Aims and scope

Abstract

Labetalol was labeled with 188Re. The reaction conditions (amounts of stannous chloride and substrate, pH, time) were optimized, and the radiochemical yield as high as 95 ± 0.4% was reached. Biodistribution in mice was studied. 188Re-Labetalol showed excellent initial heart uptake and good retention. The heart/liver ratios were 5.16, 2.70, and 2.15 at 30, 60, and 120 min post injection, respectively.

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Authors and Affiliations

  1. Labeled Compounds Department, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

    F. A. Marzook & H. M. Talaat

  2. Radioactive Isotopes and Generator Department, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

    H. E. Ramadan

Authors
  1. F. A. Marzook
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  2. H. E. Ramadan
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  3. H. M. Talaat
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Correspondence to F. A. Marzook.

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Marzook, F.A., Ramadan, H.E. & Talaat, H.M. Preparation of 188Re-Labetalol as a β1-Adrenoceptor for Use in Nuclear Medicine. Radiochemistry 61, 238–243 (2019). https://doi.org/10.1134/S1066362219020188

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  • DOI: https://doi.org/10.1134/S1066362219020188

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