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Understanding Behavior of Polycaprolactone–Gelatin Blends under High Pressure CO2

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Abstract

Polycaprolactone (PCL) is widely used in biomedical applications as electrospun fibers or porous foams. As PCL is synthetic polymer, many researchers have explored blends of PCL–gelatin to combine mechanical and bioactive properties of individual components. High pressure carbon dioxide (CO2) has been studied to foam and impregnate many biocompatible polymers. In case of PCL–gelatin blends, certain compositions can be swelled reversibly under high pressure CO2 without permanent deformation. This allows successful impregnation of PCL–gelatin blends under CO2. This study summarizes effect of different treatments adopted during impregnation process including high pressure CO2 on several blend compositions of PCL–gelatin blends. Stress relaxation, polymer melting and dissolution were observed during several treatments which affects porosity and scaffold structure significantly. Results summarized in this study will aid in optimum selection of PCL–gelatin blend composition for biomedical applications. Furthermore, CO2 solubility in polymers is restricted due to thermodynamic limitations but can be altered in the presence of a co-solvent to produce better foams. PCL can be foamed using supercritical CO2. However, CO2 foaming of PCL–gelatin blend becomes challenging to simultaneous swelling of PCL and compression of gelatin providing blend structural stability. This study has demonstrated ability of supercritical CO2 to foam PCL–gelatin blends in presence of water to create porous structure. These foams were subjected post-fabrication crosslinking and supercritical CO2 without losing porosity of foams. Thus, creating a strategy to use environmentally benign processes to fabricate, crosslink and impregnate porous scaffolds for biomedical applications.

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Authors and Affiliations

  1. Department of Chemical and Biomolecular Engineering, Ohio State University, 151 W. Woodruff Avenue, Columbus, OH, 43210, USA

    Hrishikesh Ramesh Munj & David Lane Tomasko

  2. Materials Science and Engineering, Ohio State University, 2041 College Rd N, Columbus, OH, 43210, USA

    John Joseph Lannutti

Authors
  1. Hrishikesh Ramesh Munj
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  2. John Joseph Lannutti
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  3. David Lane Tomasko
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Correspondence to Hrishikesh Ramesh Munj.

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Munj, H.R., Lannutti, J.J. & Tomasko, D.L. Understanding Behavior of Polycaprolactone–Gelatin Blends under High Pressure CO2. Polym. Sci. Ser. A 59, 866–879 (2017). https://doi.org/10.1134/S0965545X17060086

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  • DOI: https://doi.org/10.1134/S0965545X17060086

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