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Interaction of Macrocyclic Dicationic Photosensitizers with Tween 80

  • ON THE 90th ANNIVERSARY OF THE BIRTH OF G.A. KRESTOV
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Abstract

The interaction of the dicationic photosensitizers (PSs) of the porphyrin {13(3),17(3)-bis-N-(2-N',N',N'-trimethylammonioethylamide) diiodide of deuteroporphyrin-IX} and chlorin {3(1),3(2)-bis-(N,N,N-trimethylammoniomethyl)-13(1)-N-methylamide-15(2),17(3)-dimethyl ester of chlorin e6 diiodide} types with a nonionic surfactant Tween 80 (a potential delivery means) in the region of spherical micelles was studied by spectrophotometric and fluorescent titration. It was found that stable PS–Tween 80 complexes formed, with two binding modes with their own interaction constants and stoichiometry revealed on the titration curves; the most probable reasons for this are discussed. It was concluded that PS molecules lie in the outer layer of the micelle, where they are surrounded by polar oxyethylene groups and where hydrated iodide ions can penetrate. In the presence of various electrolytes, the size of Tween 80 micelles changed, which was detected by dynamic light scattering.

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Funding

This study was supported by the Russian Scientific Foundation (project no. 21-13-00398) and performed using the resources of the Multiaccess Center of the Institute of Solution Chemistry, Russian Academy of Sciences.

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Authors and Affiliations

  1. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, 153045, Ivanovo, Russia

    A. V. Kustov, S. O. Kruchin & D. V. Batov

  2. Research Institute of Macroheterocyclic Compounds, Ivanovo State University of Chemistry and Technology, 153460, Ivanovo, Russia

    A. V. Kustov & D. B. Berezin

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  1. A. V. Kustov
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  2. D. B. Berezin
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  3. S. O. Kruchin
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  4. D. V. Batov
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Correspondence to A. V. Kustov.

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Translated by L. Smolina

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Kustov, A.V., Berezin, D.B., Kruchin, S.O. et al. Interaction of Macrocyclic Dicationic Photosensitizers with Tween 80. Russ. J. Phys. Chem. 96, 793–799 (2022). https://doi.org/10.1134/S0036024422040185

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