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Genetic variability of X-linked STR markers in Siberian populations

  • Genomics. Transcriptomics
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Abstract

X-chromosome microsatellite markers are a convenient tool for studying genetic variability in human populations and DNA identification, especially during the decreased informativeness of autosomal markers. The results of genetic analysis of Siberian populations by ten X-linked microsatellite markers (DXS8378, GATA172D05, DXS7132, DXS9898, DXS7423, DXS8377, DXS101, DXS6809, DXS6789, and HPRTB) are presented. The allele frequencies, criminalistics parameters, and genetic relations between populations were calculated. The average level of expected heterozygosity (He) was 0.73 in populations. The total level of genetic differentiation in ten populations was relatively low (Fst = 0.031) compared to the level determined by autosomal and Y chromosome markers. The high probability of the establishment of differences (PD) between two unrelated individuals using a ten X-STR marker system was demonstrated. The average PD value in the panel of ten X chromosome microsatellite markers was 0.9999999997 in women and 0.999998 in men. The total level of genetic differentiation in a pool of ten populations is 0.03186.

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Authors and Affiliations

  1. Research Institute of Medical Genetics, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, 634050, Russia

    K. V. Vagaitseva, V. N. Kharkov, I. Yu. Khitrinskaya & V. A. Stepanov

  2. National Research Tomsk State University, Tomsk, 634050, Russia

    K. V. Vagaitseva, V. N. Kharkov, K. V. Cherpinskaya & V. A. Stepanov

Authors
  1. K. V. Vagaitseva
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  2. V. N. Kharkov
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  3. K. V. Cherpinskaya
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  4. I. Yu. Khitrinskaya
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  5. V. A. Stepanov
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Correspondence to K. V. Vagaitseva.

Additional information

Original Russian Text © K.V. Vagaitseva, V.N. Kharkov, K.V. Cherpinskaya, I.Yu. Khitrinskaya, V.A. Stepanov, 2015, published in Molekulyarnaya Biologiya, 2015, Vol. 49, No. 2, pp. 305–312.

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Vagaitseva, K.V., Kharkov, V.N., Cherpinskaya, K.V. et al. Genetic variability of X-linked STR markers in Siberian populations. Mol Biol 49, 267–274 (2015). https://doi.org/10.1134/S0026893315020132

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  • DOI: https://doi.org/10.1134/S0026893315020132

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