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Genetic diversity of 10 X chromosome STRs in northern Portugal

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Abstract

Genetic data of 10 X chromosome STRs (DXS8378, DXS9898, DXS8377, HPRTB, GATA172D05, DXS7423, DXS6809, DXS7132, DXS101 and DXS6789) were obtained in a sample of unrelated males born in the five northern Portuguese districts. In a global sample of 347 individuals, no shared haplotypes were found for this set of markers and single locus gene diversities were high, varying between 0.678 for DXS7423 and 0.921 for DXS8377. Linkage disequilibrium analysis did not reveal consistent evidence of association between the X-STRs used. Population comparisons of northern Portuguese districts (exact test of population differentiation; pairwise genetic distances) and analysis of molecular variance supported genetic homogeneity of this region and therefore a common genetic database was considered. In comparisons with other European data, the only population samples showing statistically significant differences to northern Portugal were Germany and Latvia. The present work demonstrates that these genetic markers are highly discriminating and therefore useful for human identification purposes and anthropological research.

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Acknowledgments

The authors would like to acknowledge Cíntia Alves for her collaboration. This work was partially supported by the Fundação para a Ciência e a Tecnologia (through grant SFRH/BD/21647/2005 and POCI, Programa Operacional Ciência e Inovação 2010).

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Authors and Affiliations

  1. Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Rua Dr. Roberto Frias, s/n, 4200-465, Porto, Portugal

    Rui Pereira, Iva Gomes, António Amorim & Leonor Gusmão

  2. Unidad de Genética Forense, Instituto de Medicina Legal, Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain

    Iva Gomes

  3. Faculdade de Ciências da Universidade do Porto, 4050, Porto, Portugal

    António Amorim

Authors
  1. Rui Pereira
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  2. Iva Gomes
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  3. António Amorim
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  4. Leonor Gusmão
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Corresponding author

Correspondence to Leonor Gusmão.

Electronic supplementary material

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Table S1

Allele frequencies and gene diversities (GD) of the 10 X-STRs in five northern Portuguese districts (DOC 118 kb)

Table S2

Single locus pairwise comparisons (genetic distance; exact test of population differentiation) between population samples from five northern Portuguese districts (first row—R ST, except for DSX9898 for which F ST was calculated; second and third rows—genetic distance and exact test of population differentiation p values) (DOC 49 kb)

Table S3

Genetic distances between northern Portuguese and other European population samples. (first row—R ST, except for DSX9898 for which F ST was calculated; second row—p value) (DOC 48 kb)

Table S4

Haplotype frequencies for DXS6809 and DXS6789 (DOC 39 kb)

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Pereira, R., Gomes, I., Amorim, A. et al. Genetic diversity of 10 X chromosome STRs in northern Portugal. Int J Legal Med 121, 192–197 (2007). https://doi.org/10.1007/s00414-006-0144-4

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  • DOI: https://doi.org/10.1007/s00414-006-0144-4

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