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The Continuous Synthesis of 2-(2'-Hydroxy-5'-Methylphenyl)Benzotriazole over Cu/γ-Al2O3

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Abstract

The samples of 20% Cu/γ-Al2O3, 20% Co/γ-Al2O3 and 20% Ni/γ-Al2O3 were prepared as hydrogenation catalysts for continuous synthesis of 2-(2'-hydroxy-5'-methylphenyl)benzotriazole. The best yield (86.62%) was afforded by the 20% Cu/γ-Al2O3 catalyst. The characterizations results obtained for the 20% Cu/γ-Al2O3 sample confirmed that Cu particles are evenly distributed over the surface of γ-Al2O3. A reduction of acid sites in the catalyst favored the selectivity to 2-(2'-hydroxy-5'-methylphenyl)benzotriazole. Furthermore, the effect of Cu content, reaction temperature, hydrogen pressure and liquid hourly space velocity was studied. Finally, 2-(2'-hydroxy-5'-methylphenyl)benzotriazole in 86.62% yield was attained under the optimized conditions.

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Funding

This work was supported by the National Natural Science Foundation of China (grant no. 21 808 161).

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Authors and Affiliations

  1. School of Chemical Engineering and Technology, Tianjin University, 300350, Tianjin, P.R. China

    L. Yan, Q. Tao, L. Liu, B. Wang & Y. Li

  2. Disha Pharmaceutical Group Co. Ltd., Tianjin, P.R. China

    L. Si

  3. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), 300072, Tianjin, P.R. China

    B. Wang & Y. Li

  4. Tianjin Engineering Research Center of Functional Fine Chemicals, Tianjin, P.R. China

    B. Wang & Y. Li

Authors
  1. L. Yan
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  2. L. Si
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  3. Q. Tao
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  4. L. Liu
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  5. B. Wang
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  6. Y. Li
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Correspondence to B. Wang or Y. Li.

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Yan, L., Si, L., Tao, Q. et al. The Continuous Synthesis of 2-(2'-Hydroxy-5'-Methylphenyl)Benzotriazole over Cu/γ-Al2O3. Kinet Catal 60, 635–641 (2019). https://doi.org/10.1134/S0023158419050124

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  • DOI: https://doi.org/10.1134/S0023158419050124

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