Abstract—
Barium-substituted tricalcium phosphates containing 0.43 and 4.28 wt % barium have been prepared via mechanochemical activation and precipitation from aqueous solutions, followed by calcination. We have determined the phase composition of the synthesized compounds and the specific surface area of the powders and evaluated their sinterability. The synthesized powders were sintered at temperatures of 1100, 1150, and 1200°C to give ceramic samples. We studied linear shrinkage of the samples during sintering, determined the bending strength of the ceramics, and examined their microstructure. The biological properties of the ceramics were studied in vitro using mesenchymal stem cells isolated from tooth pulp. The results demonstrate that the ceramics are not cytotoxic and can be used in reconstructive bone tissue surgery.
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REFERENCES
Barinov, S.M., Calcium phosphate-based ceramic and composite materials for medical applications, Usp. Khim., 2010, vol. 79, no. 1, pp. 15–32.
Lemesheva, S.A., Golovanova, O.A., and Turenkov, S.V., A detailed study of the composition of human bone tissue, Khim. Interesah Ustoich. Razvit., 2009, vol. 17, no. 3, pp. 327–332.
Radzhabova, G.T. and Rusakov, M.K., Ceramic powders from barium- and strontium-substituted tricalcium phosphates for medical applications, in Molodye Uchenye Rossii (Young Scientists of Russia), 2020, pp. 21–26.
Gerk, S.A. and Golovanova, O.A., Elemental composition of normal and pathological human bone tissue, Vestn. Omsk. Univ., 2015, vol. 78, no. 4, pp. 39–44.
Fadeeva, I.V., Bakunova, N.V., Komlev, V.S., Medvetskii, L., Fomin, A.S., Gurin, A.N., and Barinov, S.M., Zinc- and silver-substituted hydroxyapatite: synthesis and properties, Dokl. Chem., 2012, vol. 442, no. 2, pp. 63–66.
Chaikina, M.V., Bulina, N.V., Vinokurova, O.B., and Prosanov, I.Yu., Synthesis of stoichiometric and substituted β-tricalcium phosphate with the use of mechanochemistry, Khim. Interesah Ustoich. Razvit., 2020, vol. 28, no. 1, pp. 73–78.
Kingery, W.D., Introduction to Ceramics, New York: Wiley, 1965.
Inorganic Phosphate Materials, Kanazawa, T., Ed., Amsterdam: Elsevier, 1994. Translated under the title Neorganicheskie fosfatnye materialy, Kyiv: Naukova Dumka, 1998, pp. 17–109.
Belik, A.A., Izumi, F., Stefanovich, S.Y., Lazoryak, B.I., and Oikawa, K., Chemical and structural properties of a whitlockite-like phosphate, Ca9FeD(PO4)7, Chem. Mater., 2002, vol. 14, no. 9, pp. 3937–3945.https://doi.org/10.1021/cm020411+
Bakunov, V.S., Belyakov, A.V., Lukin, E.S., and Shayakhmetov, U.Sh., Oksidnaya keramika: spekanie i polzuchest' (Oxide Ceramics: Sintering and Creep), Moscow: Ross. Khim.-Tekhnol. Univ. im. D.I. Mendeleeva, 2007.
Baraiba, A.M., de Pascual, R., Camacho, M., Domingue, N., Machad, J.D., Gandi, L., and Borges, R., Distinct patterns of exocytosis elicited by Ca2+, Sr2+ and Ba2+ in bovine chromaffin cells, Pflugers Arch., 2018, vol. 470, no. 10, pp. 1459–1471.
Funding
This work was supported by the Russian Federation Ministry of Science and Higher Education, state research target no. 075-00328-21-00.
The in vitro studies were supported through the state research target no. 075-00381-21-00.
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Translated by O. Tsarev
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Fadeeva, I.V., Ryzhov, A.P., Titov, D.D. et al. Barium-Substituted Tricalcium Phosphate Ceramics. Inorg Mater 58, 317–324 (2022). https://doi.org/10.1134/S0020168522030037
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DOI: https://doi.org/10.1134/S0020168522030037