Skip to main content
SpringerLink
Log in

Tricalcium Phosphate Ceramics Doped with Silver, Copper, Zinc, and Iron (III) Ions in Concentrations of Less Than 0.5 wt.% for Bone Tissue Regeneration

  • Published:
BioNanoScience Aims and scope Submit manuscript

Abstract

Novel materials with a variety of properties, such as biocompatibility, antibacterial activity, interconnected porosity, and functionalities combined in one, are required for regenerative medicine. Porous β-tricalcium phosphate (β-TCP) ceramics doped with Cu2+, Zn2+, Ag+, and Fe3+ ions in the concentrations of less than 0.5 wt.% were synthesized and investigated. The obtained samples were analyzed by the diversity of analytical tools. The structure, solubility, and antimicrobial properties of the porous ceramics are shown to be very sensitive to the presence and the type of the cationic substituent. It opens the way to manage structure and properties of the materials for bone tissue regeneration by co-doping of the initial matrix simultaneously with different types of substituent ions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Burg, K. J. L., Porter, S., & Kellam, J. F. (2000). Biomaterial developments for bone tissue engineering. Biomaterials, 21, 2347–2359.

    Article  Google Scholar 

  2. Komaki, H., Tanaka, T., Chazono, M., & Kikuchi, T. (2006). Repair of segmental bone defects in rabbit tibiae using a complex of β-tricalcium phosphate, type I collagen, and fibroblast growth factor-2. Biomaterials, 27, 5118–5126.

    Article  Google Scholar 

  3. O’Brien, F. J. (2011). Biomaterials & scaffolds for tissue engineering. Materials today, 14, 88–95.

    Article  Google Scholar 

  4. Barinov, S. M. (2010). Calcium phosphate-based ceramic and composite materials for medicine. Russ Chem Rev, 79, 13–29.

    Article  Google Scholar 

  5. Uskovic, V., & Vu, V. M. (2016). Calcium phosphate as a key material for socially responsible tissue engineering. Materials, 9, 434(27).

    Google Scholar 

  6. Cacciotti, I. (2015). Cationic and anionic substitutions in hydroxyapatite. In I. V. Antoniac (Ed.), Handbook of bioceramics and biocomposites (p. 1068). Cham: Springer.

  7. Barinov, S. M., & Komlev, V. S. (2008). Calcium phosphate based bioceramics for bone tissue enginery. Zurich: Trans Tech. Publ.

    Google Scholar 

  8. Hughes, J. M., & Rakovan, J. (2002). The crystal structure of apatite, Ca5(PO4)3(F,OH,Cl). Rev Mineral Geochem, 48, 1–12.

    Article  Google Scholar 

  9. Gafurov, M., Biktagirov, T., Mamin, G., & Orlinskii, S. (2014). A DFT, X- and W-band EPR and ENDOR study of nitrogen-centered species in (Nano)hydroxyapatite. Appl Magn Reson, 45, 1189–1203.

    Article  Google Scholar 

  10. Biktagirov, T., Gafurov, M., Mamin, G., et al. (2014). Combination of EPR measurements and DFT calculations to study nitrate impurities in the carbonated nanohydroxyapatite. J Phys Chem A, 118, 1519–1526.

    Article  Google Scholar 

  11. Gafurov, M., Biktagirov, T., Mamin, G., et al. (2015). The interplay of manganese and nitrate in hydroxyapatite nanoparticles as revealed by pulsed EPR and DFT. Phys Chem Chem Phys, 17, 20331–20337.

    Article  Google Scholar 

  12. Gafurov, M., Biktagirov, T., Mamin, G., et al. (2016). Study of the effects of hydroxyapatite nanocrystal codoping by pulsed electron paramagnetic resonance methods. Phys Solid State, 58, 469–474.

    Article  Google Scholar 

  13. Matsunaga, K., Kubota, T., Toyoura, K., & Nakamura, A. (2015). First-principles calculations of divalent substitution of Ca2+ in tricalcium phosphates. Acta Biomater, 23, 329–337.

    Article  Google Scholar 

  14. Bandyopadhyay, A., Bernard, S., Xue, W., & Bose, S. (2006). Calcium phosphate-based resorbable ceramics: influence of MgO, ZnO, and SiO2 dopants. J Am Ceram Soc, 89(9), 2675–2688.

    Article  Google Scholar 

  15. Fielding, G. A., Bandyopadhyay, A., & Bose, S. (2012). Effects of silica and zinc oxide doping on mechanical and biological properties of 3D printed tricalcium phosphate tissue engineering scaffolds. Dent Mater, 28, 113–122.

    Article  Google Scholar 

  16. Raphel, J., Holodniy, M., Goodman, S. B., & Heilshorn, S. C. (2016). Multifunctional coatings to simultaneously promote osteointegration and prevent infection of orthopaedic implants. Biomaterials, 84, 301–314.

    Article  Google Scholar 

  17. Barinov SM, Fadeeva IV, Fomin AS, Petrakova NV. (2015) Method of obtaining porous ceramics of calcium phosphates for the treatment of bone defects. RF Patent application № 2015–112518, date of priority 07.04.2015.

  18. Fadeeva, I. V., Gafurov, M. R., Filippov, Y. Y., et al. (2016). Copper-substituted tricalcium phosphates. Dokl Chem, 471, 384–387.

    Article  Google Scholar 

  19. Fadeeva, I. V., Selezneva, I. I., Davydova, G. A., et al. (2016). Iron-substituted tricalcium phosphate ceramics. Dokl Chem, 468, 159–161.

    Article  Google Scholar 

  20. Eaton, G. R., Eaton, S. S., Barr, D. P., & Weber, R. T. (2010). Quantitative EPR (p. 185). New York: Springer, XII.

    Book  Google Scholar 

  21. Semina, N. A., Sidorenko, S. V., Rezvan, S. P., et al. (2004). Guidelines for susceptibility testing of microorganisms to antibacterial agents: methodical instructions MUK 4.2.1890-04. CMAC, 6, 306–357 [in Russian].

    Google Scholar 

  22. Balouiri, M., Sadiki, M., & Ibnsouda, S. K. (2016). Methods for in vitro evaluating antimicrobial activity: a review. J Pharm Anal, 6, 71–79.

    Article  Google Scholar 

  23. Choi, D., & Kumta, P. N. (2007). Mechano-chemical synthesis and characterization of nanostructured β-TCP powder. Mater Sci Eng C, 27, 377–381.

    Article  Google Scholar 

  24. Galukhin, A., Khelkhal, M. A., & Gerasimov, A. V. (2016). Mn-catalyzed oxidation of heavy oil in porous media: kinetics and some aspects of mechanism. Energy Fuel, 30(9), 7731–7737.

    Article  Google Scholar 

  25. Gafurov, M., Chelyshev, Y., Ignatyev, I., et al. (2016). Connection between the carotid plaque instability and paramagnetic properties of the intrinsic Mn2+ ions. BioNanoSci, 6, 558–560.

    Article  Google Scholar 

  26. Burlaka, A. P., Gafurov, M. R., Iskhakova, K. B., et al. (2016). Electron paramagnetic resonance in the experimental oncology: implementation examples of the conventional approaches. BioNanoSci., 6, 431–436.

    Article  Google Scholar 

  27. Mayer, I., Gdalya, S., Burghaus, O., & Reinen, D. (2009). A spectroscopic and structural study of M(3d)2+-doped β-tricalcium phosphate—the binding properties of Ni2+ and Cu2+ in the pseudo-octahedral Ca(5)O6 host-sites. Z Anorg Allg Chem, 635(12), 2039–2045.

    Article  Google Scholar 

  28. Schumacher, M., & Gelinsky, M. (2015). Strontium modified calcium phosphate cements—approaches towards targeted stimulation of bone turnover. J Mater Chem B, 3, 4626–4640.

    Article  Google Scholar 

  29. Kolmas, J., Groszyk, E., & Kwiatkowska-Różycka, D. (2014). Substituted hydroxyapatites with antibacterial properties. Biomed Res Int, 2014, 178123.

    Article  Google Scholar 

  30. Yavkin, B. V., Mamin, G. V., Orlinskii, S. B., et al. (2012). Pb3+ radiation defects in Ca9Pb(PO4)6(OH)2 hydroxyapatite nanoparticles studied by high-field (W-band) EPR and ENDOR. Phys Chem Chem Phys, 14(7), 2246–2249.

    Article  Google Scholar 

Download references

Acknowledgements

This work was financially supported by RFBR grant no. 15-08-06860-а, by the program of competitive growth of Kazan Federal University and the subsidy allocated to Kazan Federal University for the state assignment in the sphere of scientific activities.

Author information

Authors and Affiliations

  1. Institute of Metallurgy and Material Science RAS, Leninsky 49, Moscow, Russia, 119334

    I.V. Fadeeva, A.S. Fomin & S.M. Barinov

  2. Kazan Federal University, Kremlevskaya 18, Kazan, Russia, 420008

    M.R. Gafurov, I.A. Kiiaeva & S.B. Orlinskii

  3. Kazan State University of Architecture and Engineering, Zelenaya 1, Kazan, Russia, 420043

    L.M. Kuznetsova

  4. Research Institute of Mechanics Michurinsky 1, M.V. Lomonosov Moscow State University, Moscow, Russia, 119192

    Ya.Yu. Filippov

  5. Institute of Theoretical and Experimental Biophysics of RAS, Institutskaya 3, Puschino, Moscow, Russia, 142290

    G.A. Davydova & I.I. Selezneva

Authors
  1. I.V. Fadeeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M.R. Gafurov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I.A. Kiiaeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S.B. Orlinskii
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. L.M. Kuznetsova
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Ya.Yu. Filippov
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A.S. Fomin
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. G.A. Davydova
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. I.I. Selezneva
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. S.M. Barinov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to I.V. Fadeeva.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Dedication

MRG and SBO dedicate this work to Dr. I.N. Kurkin (Kazan) on occasion of his 75th birthday.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fadeeva, I., Gafurov, M., Kiiaeva, I. et al. Tricalcium Phosphate Ceramics Doped with Silver, Copper, Zinc, and Iron (III) Ions in Concentrations of Less Than 0.5 wt.% for Bone Tissue Regeneration. BioNanoSci. 7, 434–438 (2017). https://doi.org/10.1007/s12668-016-0386-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12668-016-0386-7

Keywords

Search

Navigation