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Mechanisms of electromechanical and electrochemical coupling in olfactory cilia of the frog (Rana temporaria)

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Abstract

The mechanisms of electromechanical and electrochemical coupling in olfactory cilia of the frog (Rana temporaria) have been investigated. High-resolution optical television microscopy of live tissue and pharmacological analysis have been used to reveal the regulation of the motility of olfactory cilia in the absence of odorants; the entry of Ca2+ ions mediated by three types of ion channels (mechanosensitive, cyclic nucleotide gated, and voltage-gated) was shown to determine the motility of cilia. Stimulation of the olfactory adenylate cyclase by movements of the cilia in the absence of odors has been demonstrated and the regulation of cilia motility by membrane potential has been revealed. Membrane potential can affect olfactory acuity and the ability to perceive weak olfactory stimuli in the absence of adequate stimulation.

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Abbreviations

OC:

olfactory cilia

СNG channels:

cyclic nucleotide-gated ion channels

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Authors and Affiliations

  1. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, 199034, Russia

    E. V. Bigdaj & V. O. Samojlov

  2. Kirov Military Medical Academy, St. Petersburg, 194044, Russia

    D. K. Fufachev & P. R. Petrov

Authors
  1. E. V. Bigdaj
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  2. D. K. Fufachev
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  3. P. R. Petrov
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  4. V. O. Samojlov
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Corresponding author

Correspondence to E. V. Bigdaj.

Additional information

Original Russian Text © E.V. Bigdaj, D.K. Fufachev, P.R. Petrov, V.O. Samojlov, 2017, published in Biofizika, 2017, Vol. 62, No. 2, pp. 311–318.

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Bigdaj, E.V., Fufachev, D.K., Petrov, P.R. et al. Mechanisms of electromechanical and electrochemical coupling in olfactory cilia of the frog (Rana temporaria). BIOPHYSICS 62, 240–246 (2017). https://doi.org/10.1134/S0006350917020051

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  • DOI: https://doi.org/10.1134/S0006350917020051

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