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Chemosensory and Mechanosensory Functions of Olfactory Cilia

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Abstract

This review presents the modern understanding of olfactory cilia as organelles that possess both chemosensory and mechanosensory properties. The molecular mechanisms that underlie heterogeneity of both olfactory transduction and locomotor activity in these cilia are described and analyzed. A hypothesis is proposed that explains the extremely high sensitivity of the olfactory system by the contribution of both chemical and mechanical properties of olfactory cilia. The article includes analysis of the literature and original experimental data.

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ACKNOWLEDGMENTS

This work was financially supported by the Basic Research Program for 2014–2020 of the State Academies of Sciences (GP-14, section 63).

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Authors and Affiliations

  1. Pavlov Institute of Physiology, Russian Academy of Sciences, 199034, St. Petersburg, Russia

    E. V. Bigday & V. O. Samojlov

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  1. E. V. Bigday
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  2. V. O. Samojlov
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Correspondence to E. V. Bigday.

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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

Additional information

Translated by D. Timchenko

Abbreviations used: OC, olfactory cilia; OR, olfactory receptor.

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Bigday, E.V., Samojlov, V.O. Chemosensory and Mechanosensory Functions of Olfactory Cilia. BIOPHYSICS 63, 925–930 (2018). https://doi.org/10.1134/S0006350918060027

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