Skip to main content
SpringerLink
Log in

Biosynthesis of biologically active low-molecular weight compounds by fungi of the genus Penicillium (Review)

  • To the 50th Anniversary of the Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences
  • Published:
Applied Biochemistry and Microbiology Aims and scope Submit manuscript

Abstract

The recent data on exometabolite biosynthesis in fungi of the genus Penicillium is summarized. The study of creative species, as well as those isolated from extreme ecotopes, resulted in the identification of a number of novel, biologically active compounds. Alkaloid biosynthesis has been shown to begin on the first day of fungus cultivation and to proceed throughout the cultivation period. Idiophase kinetics was observed for the biosynthesis of polyketide metabolites. The mechanisms of regulation of biosynthesis of promising bioactive compounds are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Samson, R.A. and Frisvad, J.C., Stud. Mycol., 2004, vol. 49, no. 1, pp. 1–241.

    Google Scholar 

  2. Kozlovskii, A.G., Vinokurova, N.G., Zhelifonova, V.P., Adanin, V.M., and Ozerskaya, S.M., Microbiology (Moscow), 1997, vol. 66, no. 5, pp. 501–504.

    CAS  Google Scholar 

  3. Zhelifonova, V.P., Antipova, T.V., and Kozlovskii, A.G., Microbiology (Moscow), 2006, vol. 75, no. 5, pp. 742–746..

    CAS  Google Scholar 

  4. Kozlovskii, A.G., Vinokurova, N.G., Zhelifonova, V.P., and Ozerskaya, S.M., Microbiology (Moscow), 1997, vol. 66, no. 4, pp. 429–433.

    CAS  Google Scholar 

  5. Kozlovskii, A.G., Vinokurova, N.G., Zhelifonova, V.P., and Adanin, M.M., Appl. Biochem. Microbiol., 1997, vol. 33, no. 1, pp. 61–64.

    Google Scholar 

  6. Kozlovskii, A.G., Vinokurova, N.G., and Adanin, V.M., Appl. Biochem. Microbiol., 2000, vol. 36, no. 3, pp. 271–275.

    Article  Google Scholar 

  7. Kozlovskii, A.G., Zhelifonova, V.P., Adanin, V.M., Antipova, T.V., Shnyreva, A.V., and Viktorov, A.I., Microbiology (Moscow), 2002, vol. 71, no. 6, pp. 666–669.

    Article  CAS  Google Scholar 

  8. Kozlovskii, A.G., Zhelifonova, V.P., Adanin, V.M., Antipova, T.V., Ozerskaya, S.M., Kochkina, G.A., and Grefe, U., Microbiology (Moscow), 2003, vol. 72, no. 6, pp. 723–727.

    Article  CAS  Google Scholar 

  9. Kozlovsky, A.G., Zhelifonova, V.P., Adanin, V.M., Antipova, T.V., Ozerskaya, S.M., Kochkina, G.A., and Gräfe, U., Appl. Biochem. Microbiol., 2003, vol. 39, no. 4, pp. 393–397.

    Article  CAS  Google Scholar 

  10. Kozlovsky, A.G., Zhelifonova, V.P., Antipova, T.V., Adanin, V.M., Novikova, N.D., Deshevaya, E.A., Schlegel, B., Dahse, H.M., Gollmik, F., and Gräfe, U., Appl. Biochem. Microbiol., 2004, vol. 40, no. 3, pp. 291–295.

    Article  CAS  Google Scholar 

  11. Antipova, T.V., Zhelifonova, V.P., Kochkina, G.A., and Kozlovskii, A.G., Microbiology (Moscow), 2008, vol. 77, no. 4, pp. 446–450.

    Article  CAS  Google Scholar 

  12. Antipova, T.V., Zhelifonova, V.P., Baskunov, B.P., Ozerskaya, S.M., Ivanushkina, N.E., and Kozlovsky, A.G., Appl. Biochem. Microbiol., 2011, vol. 47, no. 3, pp. 288–292.

    Article  CAS  Google Scholar 

  13. Kozlovskii, A.G., Zhelifonova, V.P., Antipova, T.V., Baskunov, B.P., Kochkina, G.A., and Ozerskaya, S.M., Microbiology (Moscow), 2012, vol. 81, no. 3, pp. 306–311.

    Article  CAS  Google Scholar 

  14. Kozlovsky, A.G., Zhelifonova, V.P., Antipova, T.V., Baskunov, B.P., Ivanushkina, N.E., and Ozerskaya, S.M., Food Addit. Contaminants, 2014, vol. 31, no. 2, pp. 300–306.

    Article  CAS  Google Scholar 

  15. RF Patent No. 2014620181, 2014.

  16. Kozlovskii, A.G., Zelenkova, N.F., Adanin, V.M., Sakharovskii, V.G., and Arinbasarov, M.U., Prikl. Biokhim. Mikrobiol., 1995, vol. 31, no. 5, pp. 540–544.

    CAS  Google Scholar 

  17. Kozlovskii, A.G., Vinokurova, N.G., Adanin, V.M., and Sedmera, P., Appl. Biochem. Microbiol., 1997, vol. 33, no. 4, pp. 364–369.

    Google Scholar 

  18. Kozlovsky, A.G., Vinokurova, N.G., Adanin, V.M., Burkhard, G.H., Dahse, M., and Graefe, U., J. Nat. Prod., 2000, vol. 63, no. 5, pp. 698–700.

    Article  CAS  PubMed  Google Scholar 

  19. Vinokurova, N.G., Adanin, V.M., and Grafe, U., Nat. Prod. Lett., 2000, vol. 14, no. 5, pp. 333–340.

    Article  Google Scholar 

  20. Shnyreva, A.V., Sizova, T.P., Bragina, M.P., Viktorov, A.N., and D’yakov, Yu.T., Mikol. Fitopatol., 2001, vol. 35, no. 3, pp. 37–42.

    Google Scholar 

  21. Ozerskaya, S., Kochkina, G., Ivanushkina, N., and Gilichinsky, D., in Permafrost Soils, Margesin, R., Ed., Berlin, Heidelberg: Springer Verlag, 2009, pp. 85–95.

  22. Robinson, C.H., New Phytol., 2001, vol. 151, no. 2, pp. 341–353.

    Article  CAS  Google Scholar 

  23. Kozlovsky, A.G., Zhelifonova, V.P., and Antipova, T.V., in Permafrost: Distribution, Composition, and Impact on Infrastructure and Ecosystems, Pokrovsky, O.S., Ed., New York: Nova Science Publishers, 2014, pp. 265–280.

  24. Kozlovsky, A.G., Zhelifonova, V.P., Antipova, T.V., Adanin, V.M., Kochkina, G.A., Ozerskaya, S.M., Schlegel, B., Dahse, H.M., Gollmick, F.A., and Gräfe, U., J. Antibiot., 2003, vol. 56, no. 5, pp. 488–491.

    Article  CAS  PubMed  Google Scholar 

  25. Zhelifonova, V.P., Antipova, T.V., Ozerskaya, S.M., Kochkina, G.A., and Kozlovsky, A.G., Microbiology (Moscow), 2009, vol. 78, no. 3, pp. 350–354.

    Article  CAS  Google Scholar 

  26. Zhelifonova, V.P., Antipova, T.V., and Kozlovsky, A.G., Microbiology (Moscow), 2010, vol. 79, no. 3, 277–286.

    Article  CAS  Google Scholar 

  27. Bu, Lock J.D., Adv. Appl. Microbiol., 1961, vol. 3, pp. 293–342.

    Article  Google Scholar 

  28. Kozlovskii, A.G., Zhelifonova, V.P., Vinokurova, N.G., and Adanin, V.M., Microbiology (Moscow), 1997, vol. 66, no. 5, pp. 501–504.

    CAS  Google Scholar 

  29. Kozlovsky, A.G., Zhelifonova, V.P., and Antipova, T.V., Appl. Biochem. Microbiol., 2009, vol. 45, no. 2, pp. 182–186.

    Article  CAS  Google Scholar 

  30. Kozlovsky, A.G., Zhelifonova, V.P., and Antipova, T.V., Appl. Biochem. Microbiol., 2005, vol. 41, no. 5, pp. 499–502.

    Article  CAS  Google Scholar 

  31. Zhelifonova, V.P., Antipova, T.V., and Kozlovskii, A.G., Appl. Biochem. Microbiol., 2012, vol. 48, no. 4, pp. 302–307.

    Article  CAS  Google Scholar 

  32. Kozlovskii, A.G., Zhelifonova, V.P., and Antipova, T.V., Microbiology (Moscow), 2006, vol. 75, no. 3, pp. 279–285.

    Article  CAS  Google Scholar 

  33. Rehachek, Z. and Sajdl, P., Ergot Alkaloids. Chemistry, Biological Effect, Biotechnology, Praha: Academia, 1990.

    Google Scholar 

  34. Zhelifonova, V.P., Maier, A., and Kozlovskii, A.G., Appl. Biochem. Microbiol., 2008, vol. 44, no. 6, pp. 608–612.

    Article  CAS  Google Scholar 

  35. Kozlovsky, A.G., Zhelifonova, V.P., Antipova, T.V., and Zelenkova, N.F., Appl. Biochem. Microbiol., 2010, vol. 46, no. 5, pp. 525–529.

    Article  CAS  Google Scholar 

  36. Medentsev, A.G. and Akimenko, V.K., Phytochemistry, 1998, vol. 47, no. 6, pp. 935–959.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Skryabin Institute of Biochemistry and Physiology of Microorganisms of the Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia

    A. G. Kozlovskii, T. V. Antipova & V. P. Zhelifonova

Authors
  1. A. G. Kozlovskii
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. V. Antipova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. P. Zhelifonova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. G. Kozlovskii.

Additional information

Original Russian Text © A.G. Kozlovskii, T.V. Antipova, V.P. Zhelifonova, 2015, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2015, Vol. 51, No. 2, pp. 236–242.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kozlovskii, A.G., Antipova, T.V. & Zhelifonova, V.P. Biosynthesis of biologically active low-molecular weight compounds by fungi of the genus Penicillium (Review). Appl Biochem Microbiol 51, 236–241 (2015). https://doi.org/10.1134/S0003683815020118

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0003683815020118

Keywords

Search

Navigation