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Neuropsychopharmacology in Addiction Treatment

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Neuroimaging and Psychosocial Addiction Treatment

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Abstract

There is a great deal of interest in understanding addiction neurobiology and in translating findings from pre-clinical studies to clinical samples. Functional magnetic resonance imaging (fMRI) represents an important tool in translating pre-clinical insights to brain function in humans affected by addictive disorders. While there has been a focus on developing fMRI-based biomarkers for psychiatric disorders in general (Fu & Costafreda, 2013), the field of addictions has yet to identify reliable biomarkers, fMRI based or otherwise. Importantly, diagnostic and prognostic biomarkers are only as useful as their ability to add value to existing clinical and behavioral systems. Perhaps most promising is the notion that understanding addiction neurobiology at the level of the individual’s brain function will allow for the development of more efficacious treatments, including the prediction of relapse and the test of promising behavioral and pharmacological interventions. In particular, it has been argued that therapies for addiction must target brain structures that are altered by the disorder through neuropsychological and pharmacological interventions (Konova et al., 2013b). Further, studies suggest that functional neuroimaging provides an objective and quantifiable measure for evaluating changes associated with treatment beyond what can be gathered from self-report or behavior alone (Menossi et al., 2013).

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References

  • Bach, P., Vollstädt-Klein, S., Frischknecht, U., Hoerst, M., Kiefer, F., Mann, K., … Hermann, D. (2012). ‘Diminished brain functional magnetic resonance imaging activation in patients on opiate maintenance despite normal spatial working memory task performance’, Clinical Neuropharmacology, 35, 153–60.

    Article  PubMed  Google Scholar 

  • Beck, A., Wustenberg, T., Genauck, A., Wrase, J., Schlagenhauf, F., Smolka, M. N., … Heinz, A. (2012). ‘Effect of brain structure, brain function, and brain connectivity on relapse in alcohol-dependent patients’, Archives of General Psychiatry, 69, 842–52.

    Article  PubMed  Google Scholar 

  • Boettiger, C. A., Kelley E. A., Mitchell, J. M., D’Esposito, M., & Fields, H. L. (2009). ‘Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network’, Pharmacology Biochemistry and Behavior, 93(3), 291–9.

    Article  Google Scholar 

  • Brewer J. A., Worhunsky, P. D., Carroll, K. M., Rounsaville, B. J., & Potenza, M. N. (2008). ‘Pretreatment brain activation during Stroop task is associated with outcomes in cocaine-dependent patients’, Biological Psychiatry, 64, 998–1004.

    Article  PubMed  PubMed Central  Google Scholar 

  • Chase, H. W., Eickhoff, S. B., Laird, A. R., & Hogarth, L. (2011). ‘The neural basis of drug stimulus processing and craving: An activation likelihood estimation meta-analysis’, Biological Psychiatry, 70, 785–93.

    Article  PubMed  Google Scholar 

  • Clark, V. P., Beatty G. K., Anderson, R. E., Kodituwakku, P., Phillips, J. P., Lane, T. D., … Calhoun, V. D. (2014). ‘Reduced fMRI activity predicts relapse in patients recovering from stimulant dependence’, Human Brain Mapping, 35, 414–28.

    Article  PubMed  PubMed Central  Google Scholar 

  • Claus, E. D., Feldstein Ewing, S. W., Filbey, F. M., Sabbineni, A., & Hutchison, K. E. (2011). ‘Identifying neurobiological phenotypes associated with alcohol use disorder severity’, Neuropsychopharmacology, 36, 2086–96.

    Article  PubMed  PubMed Central  Google Scholar 

  • Cosgrove, K. P., Batis, J., Bois, F., Maciejewski, P. K., Esterlis, L, Kloczynski, T., … Staley J. K. (2009). ‘beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking’, Archives of General Psychiatry, 66, 666–76.

    Article  PubMed  PubMed Central  Google Scholar 

  • Courtney, K. E., Ghahremani, D. G., London, E. D., & Ray L. A. (2014). ‘The association between cue-reactivity in the precuneus and level of dependence on nicotine and alcohol’, Drug and Alcohol Dependence, 141, 21–6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Culbertson, C. S., Bramen, J., Cohen, M. S., London, E. D., Olmstead, R. E., Gan, J. J., … Brody A. L. (2011). ‘Effect of bupropion treatment on brain activation induced by cigarette-related cues in smokers’, Archives of General Psychiatry, 68, 505–15.

    Article  PubMed  PubMed Central  Google Scholar 

  • Engelmann, J. M., Versace, F., Robinson, J. D., Minnix, J. A., Lam, C. Y., Cui, Y., … Cinciripini, P. M. (2012). ‘Neural substrates of smoking cue reactivity: A metaanalysis of fMRI studies’, NeuroImage, 60, 252–62.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ersche, K. D., Bullmore, E. T, Craig, K.J., Shabbir, S. S., Abbott, S., Müller, U., … Robbins, T. W. (2010). ‘Influence of compulsivity of drug abuse on dopaminergic modulation of attentional bias in stimulant dependence’, Archives of General Psychiatry, 67, 632–44.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ersche, K. D., Roiser, J. P., Abbott, S., Craig, K. J., Müller, U., Suckling, J., … Bullmore, E. T. (2011). ‘Response perseveration in stimulant dependence is associated with striatal dysfunction and can be ameliorated by a D(2/3) receptor agonist’, Biological Psychiatry, 70, 754–62.

    Article  PubMed  Google Scholar 

  • Feldstein Ewing, S. W., & Chung, T. (2013). ‘Neuroimaging mechanisms of change in psychotherapy for addictive behaviors: Emerging translational approaches that bridge biology and behavior’, Psychology of Addictive Behaviors, 27, 329–35.

    Article  Google Scholar 

  • Forman, S. D., Dougherty, G. G., Casey, B. J., Siegle, G. J., Braver, T. S., Barch, D. M., … Lorenson, E. (2004). ‘Opiate addicts lack error-dependent activation of rostral anterior cingulate’, Biological Psychiatry, 55, 531–37.

    Article  PubMed  Google Scholar 

  • Fox, H. C., Seo, D., Tuit, K., Hansen, J., Kimmerling, A., Morgan, P. T., & Sinha, R. (2012). ‘Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: Preliminary findings’, Journal of Psychopharmacology 26, 958–72.

    Article  PubMed  PubMed Central  Google Scholar 

  • Franklin, T. R., Harper, D., Kampman, K., Kildea-McCrea, S., Jens, W., Lynch, K. G., … Childress, A. R. (2009). ‘The GABA B agonist baclofen reduces cigarette consumption in a preliminary double-blind placebo-controlled smoking reduction study’, Drug and Alcohol Dependence, 103, 30–6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Franklin, T. R., Shin, J., Jagannathan, K., Suh, J. J., Detre, J. A., O’Brien, C. P., & Childress, A. R. (2012). ‘Acute baclofen diminishes resting baseline blood flow to limbic structures: A perfusion fMRI study’, Drug and Alcohol Dependence, 125, 60–6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Franklin, T. R., Wang, Z., Sciortino, N., Harper, D., Li, Y., Hakun, J., … Childress, A. R. (2011). ‘Modulation of resting brain cerebral blood flow by the GABA B agonist, baclofen: A longitudinal perfusion fMRI study’, Drug and Alcohol Dependence, 117, 176–83.

    Article  PubMed  PubMed Central  Google Scholar 

  • Franklin, T. R., Wang, Z., Suh, J. J., Hazan, R., Cruz, J., Li, Y., … Childress, A. R. (2011). ‘Effects of varenicline on smoking cue-triggered neural and craving responses’, Archives of General Psychiatry, 68, 516–26.

    Article  PubMed  PubMed Central  Google Scholar 

  • Fu, C. H., & Costafreda, S. G. (2013). ‘Neuroimaging-based biomarkers in psychiatry: Clinical opportunities of a paradigm shift’, Canadian Journal of Psychiatry, 58(9), 499–508.

    PubMed  Google Scholar 

  • Ghahremani, D. G., Tabibnia, G., Monterosso, J., Hellemann, G., Poldrack, R. A., & London, E. D. (2011). ‘Effect of modafinil on learning and task-related brain activity in methamphetamine-dependent and healthy individuals’, Neuropsychopharmacology, 36(5), 950–9.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gilman, J. M., Ramchandani, V. A., Davis, M. B., Bjork, J. M., & Hommer, D. W. (2008). ‘Why we like to drink: A functional magnetic resonance imaging study of the rewarding and anxiolytic effects of alcohol’, The Journal of Neuroscience, 28, 4583–91.

    Article  PubMed  PubMed Central  Google Scholar 

  • Goldstein, R. Z., & Volkow, N. D. (2011). ‘Dysfunction of the prefrontal cortex in addiction: Neuroimaging findings and clinical implications’, Nature Reviews Neuroscience, 12, 652–69.

    Article  PubMed  PubMed Central  Google Scholar 

  • Goldstein, R. Z., Woicik, P. A., Maloney T, Tomasi, D., Alia-Klein, N., Shan, J., … Volkow, N. D. (2010). ‘Oral methylphenidate normalizes cingulate activity in cocaine addiction during a salient cognitive task’, Proceedings of the National Academy of Sciences of the United States of America, 107, 16667–72.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gotti, C., Zoli, M., & Clementi, F. (2006). ‘Brain nicotinic acetylcholine receptors: Native subtypes and their relevance’, Trends in Pharmacological Sciences, 27, 482–91.

    Article  PubMed  Google Scholar 

  • Goudriaan, A. E., Veltman, D. J., van den Brink, W., Dom, G., & Schmaal, L. (2013). ‘Neurophysiological effects of modafinil on cue-exposure in cocaine dependence: A randomized placebo-controlled cross-over study using pharmacological fMRI’, Addictive Behaviors, 38, 1509–17.

    Article  PubMed  Google Scholar 

  • Gradin, V B., Baldacchino, A., Balfour, D., Matthews, K., Steele, J. D. (2014). ‘Abnormal brain activity during a reward and loss task in opiate-dependent patients receiving methadone maintenance therapy’, Neuropsychopharmacology, 39, 885–94.

    Article  PubMed  PubMed Central  Google Scholar 

  • Grüsser, S. M., Wrase, J., Klein, S., Hermann, D., Smolka, M. N., Ruf, M., … Heinz, A. (2004). ‘Cue-induced activation of the striatum and medial prefrontal cortex is associated with subsequent relapse in abstinent alcoholics’, Psychopharmacology (Berlin, Germany), 175, 296–302.

    Article  Google Scholar 

  • Han, D. H., Kim, S. M., Choi, J. E., Min, K. J., & Renshaw, P. F. (2013). ‘Adjunctive aripiprazole therapy with escitalopram in patients with co-morbid major depressive disorder and alcohol dependence: Clinical and neuroimaging evidence’, Journal of Psychopharmacology, 27, 282–91.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hasin, D. S., O’Brien, C. P., Auriacombe, M., Borges, G., Bucholz, K., Budney A., … Grant, B. F. (2013). ‘DSM-5 criteria for substance use disorders: Recommendations and rationale. American Journal of Psychiatry, 170, 834–51.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hermann, D., Smolka, M. N., Wrase, J., Klein, S., Nikitopoulos, J., Georgi, A., … Heinz, A. (2006). ‘Blockade of cue-induced brain activation of abstinent alcoholics by a single administration of amisulpride as measured with fMRI’, Alcoholism: Clinical and Experimental Research, 30, 1349–54.

    Article  Google Scholar 

  • Hutchison, K. E. (2008). ‘Alcohol dependence: Neuroimaging and the development of translational phenotypes’, Alcoholism: Clinical and Experimental Research, 32, 1111–12.

    Article  Google Scholar 

  • Janes, A. C., Pizzagalli, D. A., Richardt, S., Frederick, B. deB., Chuzi, S., Pachas, G., … Kaufman, M. J. (2010). ‘Brain reactivity to smoking cues prior to smoking cessation predicts ability to maintain tobacco abstinence’, Biological Psychiatry, 67, 722–29.

    Article  PubMed  PubMed Central  Google Scholar 

  • Jasinska, A. J., Chua, H. F., Ho, S. S., Polk, T. A., Rozek, L. S., & Strecher, V. J. (2012). ‘Amygdala response to smoking-cessation messages mediates the effects of serotonin transporter gene variation on quitting’, Neuroimage, 60, 766–73.

    Article  PubMed  PubMed Central  Google Scholar 

  • Jasinska, A. J., Stein, E. A., Kaiser, J., Naumer, M. J., & Yalachkov, Y. (2014). ‘Factors modulating neural reactivity to drug cues in addiction: A survey of human neuroimaging studies’, Neuroscience & Biobehavioral Reviews, 38, 1–16.

    Article  Google Scholar 

  • Jasinska, A. J., Stein, E. A., Kaiser, J., Naumer, M. J., & Yalachkov, Y. (2014). ‘Factors modulating neural reactivity to drug cues in addiction: A survey of human neuroimaging studies’, Neuroscience & Biobehavioral Reviews, 38, 1–16.

    Article  Google Scholar 

  • Jiang, G. H., Qiu, Y. W., Zhang, X. L., Han, L. J., Lv, X. F., Li, L. M., … Tian, J. Z. (2011). ‘Amplitude low-frequency oscillation abnormalities in the heroin users: A resting state fMRI study’, Neuroimage, 57, 149–54.

    Article  PubMed  Google Scholar 

  • Kalivas, P. W., & Volkow, N. D. (2005). ‘The neural basis of addiction: A pathology of motivation and choice’, American Journal of Psychiatry, 162, 1403–13.

    Article  PubMed  Google Scholar 

  • Konova, A. B., Moeller, S. J., & Goldstein, R. Z. (2013). ‘Common and distinct neural targets of treatment: Changing brain function in substance addiction’, Neuroscience & Biobehavioral Reviews, 37, 2806–17.

    Article  Google Scholar 

  • Konova, A. B., Moeller, S. J., Tomasi, D., Volkow, N. D., & Goldstein, R. Z. (2013). ‘Effects of methylphenidate on resting-state functional connectivity of the mesocorticolimbic dopamine pathways in cocaine addiction’, JAMA Psychiatry, 70, 857–68.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kosten, T. R., Scanley B. E., Tucker, K. A., Oliveto, A., Prince, C., Sinha, R., … Wexler, B. E. (2006). ‘Cue-induced brain activity changes and relapse in cocaine-dependent patients’, Neuropsychopharmacology, 31, 644–50.

    Article  PubMed  Google Scholar 

  • Langleben, D. D., Ruparel, K., Elman, I., Busch-Winokur, S., Pratiwadi, R., Loughead, J., … Childress, A. R. (2008). ‘Acute effect of methadone maintenance dose on brain fMRI response to heroin-related cues’, American Journal of Psychiatry, 165, 390–4.

    Article  PubMed  Google Scholar 

  • Langosch, J. M., Spiegelhalder, K., Jahnke, K., Feige, B., Regen, W., Kiemen, A., … Olbrich, H. M. (2012). ‘The impact of acamprosate on cue reactivity in alcohol dependent individuals: A functional magnetic resonance imaging study’, Journal of Clinical Psychopharmacology, 32, 661–5.

    Article  PubMed  Google Scholar 

  • Li, C. S., Morgan, P. T, Matuskey, D., Abdelghany, O., Luo, X., Chang, J. L., … Malison, R. T. (2010). ‘Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients’, Proceedings of the National Academy of Sciences of the United States of America, 107, 14455–9.

    Article  PubMed  PubMed Central  Google Scholar 

  • Litten, R. Z., Egli, M., Heilig, M., Cui, C., Fertig, J. B., Ryan, M. L., … Noronha, A. (2012). ‘Medications development to treat alcohol dependence: A vision for the next decade’, Addiction Biology, 17, 513–27.

    Article  PubMed  PubMed Central  Google Scholar 

  • Loughead, J., Ray R., Wileyto, E. P., Ruparel, K., O’Donnell, G. P., Senecal, N., … Lerman, C. (2013). ‘Brain activity and emotional processing in smokers treated with varenicline’, Addiction Biology, 18, 732–8.

    Article  PubMed  Google Scholar 

  • Loughead, J., Ray R., Wileyto, E. P., Ruparel, K., Sanborn, P., Siegel, S., … Lerman C. (2010). ‘Effects of the α4β2 partial agonist varenicline on brain activity and working memory in abstinent smokers’, Biological Psychiatry, 67, 715–21.

    Article  PubMed  Google Scholar 

  • Lukas, S. E., Lowen, S. B., Lindsey K. P., Conn, N., Tartarini, W., Rodolico, J., … Penetar, D. M. (2013). ‘Extended-release naltrexone (XR-NTX) attenuates brain responses to alcohol cues in alcohol-dependent volunteers: A bold fMRI study’, Neuroimage 78, 176–85.

    Article  PubMed  Google Scholar 

  • Ma, N., Liu, Y., Li, N., Wang, C. X., Zhang, H., Jiang, X. F., … Zhang, D. R. (2010). ‘Addiction related alteration in resting-state brain connectivity’, Neuroimage, 49, 738–44.

    Article  PubMed  PubMed Central  Google Scholar 

  • Mann, K., Kiefer, F., Smolka, M., Gann, H., Wellek, S., Heinz, A., & the PREDICT Study Research Team. (2009). ‘Searching for responders to acamprosate and naltrexone in alcoholism treatment: Rationale and design of the PREDICT study’, Alcoholism: Clinical and Experimental Research, 33, 674–83.

    Article  Google Scholar 

  • Marhe, R., Luijten, M., van de Wetering, B. J., Smits, M., & Franken, I. H. (2013). ‘Individual differences in anterior cingulate activation associated with attentional bias predict cocaine use after treatment’, Neuropsychopharmacology, 38, 1085–93.

    Article  PubMed  PubMed Central  Google Scholar 

  • Marvel, C. L., Faulkner, M. L., Strain, E. C., Mintzer, M. Z., & Desmond, J. E. (2012). ‘An fMRI investigation of cerebellar function during verbal working memory in methadone maintenance patients’, Cerebellum, 11, 300–10.

    Article  PubMed  PubMed Central  Google Scholar 

  • Matuskey, D., Luo, X., Zhang, S., Morgan, P. T, Abdelghany, O., Malison, R. T, & Li, C. S. (2013). ‘Methylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals’, Psychiatry Research, 214, 116–21.

    Article  PubMed  Google Scholar 

  • McClernon, F. J., Hiott, F. B., Liu, J., Salley A. N., Behm, F. M., & Rose, J. E. (2007). ‘Selectively reduced responses to smoking cues in amygdala following extinction-based smoking cessation: Results of a preliminary functional magnetic resonance imaging study’, Addiction Biology, 12, 503–12.

    Article  PubMed  Google Scholar 

  • McHugh, M. J., Deniers, C. H., Salmeron, B. J., Devous Sr., M. D., Stein, E. A., & Adinoff, B. (2014). ‘Cortico-amygdala coupling as a marker of early relapse risk in cocaine-addicted individuals’, Front Psychiatry, 5.

    Google Scholar 

  • Mei, W., Zhang, J. X., & Xiao, Z. (2010). ‘Acute effects of sublingual buprenorphine on brain responses to heroin-related cues in early-abstinent heroin addicts: An uncontrolled trial’, Neuroscience, 170, 808–15.

    Article  PubMed  Google Scholar 

  • Menossi, H. S., Goudriaan, A. E., de Azevedo-Marques Périco, C., Nicastri, S., de Andrade, A. G., D’Elia, G., … Castaldelli-Maia, J. M. (2013). ‘Neural bases of pharmacological treatment of nicotine dependence — insights from functional brain imaging: A systematic review’, CNS Drugs, 27, 921–41.

    Article  PubMed  Google Scholar 

  • Mihalak, K. B., Carroll, F. I., & Luetje, C. W. (2006). ‘Varenicline is a partial agonist at α4β2 and a full agonist at α7 neuronal nicotinic receptors’, Molecular Pharmacology, 70, 801–5.

    Article  PubMed  Google Scholar 

  • Mitchell, J. M., Tavares, V. C., Fields, H. L., D’Esposito, M., & Boettiger, C. A. (2007). ‘Endogenous opioid blockade and impulsive responding in alcoholics and healthy controls’, Neuropsychopharmacology 32, 439–49.

    Article  PubMed  Google Scholar 

  • Mitchell, M. R., Balodis, I. M., DeVito, E. E., Lacadie, C. M., Yeston, J., Scheinost, D., … Potenza, M. N. (2013). ‘A preliminary investigation of Stroop-related intrinsic connectivity in cocaine dependence: Associations with treatment outcomes’, The American Journal of Drug and Alcohol Abuse, 39, 392–402.

    Article  PubMed  Google Scholar 

  • Moeller, R G., Steinberg, J. L., Schmitz, J. M., Ma, L., Liu, S., Kjome, K. L., … Narayana, P. A. (2010). Working memory fMRI activation in cocaine-dependent subjects: Association with treatment response’, Psychiatry Research, 181, 174–82.

    Article  PubMed  PubMed Central  Google Scholar 

  • Monti, P. M., Tidey J., Czachowski, C. L., Grant, K. A., Rohsenow, D. J., Sayette, M., … Pierre, P. (2004). ‘Building bridges: The transdisciplinary study of craving from the animal laboratory to the lamppost’, Alcoholism: Clinical and Experimental Research, 28, 279–87.

    Article  Google Scholar 

  • Myrick, H., Anton, R. R, Li, X., Henderson, S., Drobes, D., Voronin, K., & George, M. S. (2004). ‘Differential brain activity in alcoholics and social drinkers to alcohol cues: Relationship to craving’, Neuropsychopharmacology, 29, 393–402.

    Article  PubMed  Google Scholar 

  • Myrick, H., Anton, R. R, Li, X., Henderson, S., Randall, P. K., & Voronin, K. (2008). ‘Effect of naltrexone and ondansetron on alcohol cue-induced activation of the ventral striatum in alcohol-dependent people’, Archives of General Psychiatry, 65, 466–75.

    Article  PubMed  PubMed Central  Google Scholar 

  • Myrick, H., Li, X., Randall, P. K., Henderson, S., Voronin, K., & Anton, R. R (2010). ‘The effect of aripiprazole on cue-induced brain activation and drinking parameters in alcoholics’, Journal of Clinical Psychopharmacology, 30, 365–72.

    Article  PubMed  PubMed Central  Google Scholar 

  • Parvaz, M. A., Alia-Klein, N., Woicik, P. A., Volkow, N. D., & Goldstein, R. Z. (2011). ‘Neuroimaging for drug addiction and related behaviors’, Reviews in the Neurosciences, 22, 609–24.

    Article  PubMed  PubMed Central  Google Scholar 

  • Paulus, M. P., Tapert, S. R, & Schuckit, M. A. (2005). ‘Neural activation patterns of methamphetamine-dependent subjects during decision making predict relapse’, Archives of General Psychiatry, 62, 761–8.

    Article  PubMed  Google Scholar 

  • Prisciandaro, J. J., Myrick, H., Henderson, S., McRae-Clark, A. L., Santa Ana, E. J., Saladin, M. E., … Brady, K. T. (2013). ‘Impact of DCS-facilitated cue exposure therapy on brain activation to cocaine cues in cocaine dependence’, Drug and Alcohol Dependence, 132, 195–201.

    Article  PubMed  PubMed Central  Google Scholar 

  • Qiu, Y. W., Han, L. J., Lv, X. F., Jiang, G. H., Tian, J. Z., Zhuo, F. Z., … Zhang, X. L. (2011). ‘Regional homogeneity changes in heroin-dependent individuals: Resting-state functional MR imaging study’, Radiology, 261, 551–9.

    Article  PubMed  Google Scholar 

  • Ray L. A., Barr, C. S., Blendy J. A., Oslin, D., Goldman, D., & Anton, R. F. (2012). ‘The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: A critical review’, Alcoholism: Clinical and Experimental Research, 36, 385–94.

    Article  Google Scholar 

  • Ray, L. A., Courtney, K. E., Ghahremani, D. G., Miotto, K., Brody A., & London, E. D. (2014). ‘Varenicline, naltrexone, and their combination for heavy-drinking smokers: Preliminary neuroimaging findings’, The American Journal of Drug and Alcohol Abuse, 20, 1–10.

    Google Scholar 

  • Robinson, T. E., & Berridge, K. C. (1993). ‘The neural basis of drug craving: An incentive-sensitization theory of addiction’, Brain Research Reviews, 18, 247–91.

    Article  PubMed  Google Scholar 

  • Rollema, H., Chambers, L. K., Coe, J. W., Glowa, J., Hurst, R. S., Lebel, L. A., … Williams, K. E. (2007). ‘Pharmacological profile of the α4α2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid’, Neuropharmacology, 52, 985–94.

    Article  PubMed  Google Scholar 

  • Rollema, H., Hajos, M., Seymour, P. A., Kozak, R., Majchrzak, M. J., Guanowsky V., … Williams K. E. (2009). ‘Preclinical pharmacology of the α4β2 nAChR partial agonist varenicline related to effects on reward, mood and cognition’, Biochemical Pharmacology, 78, 813–24.

    Article  PubMed  Google Scholar 

  • Sarter, M., Parikh, V., & Howe, W. M. (2009). ‘nAChR agonist-induced cognition enhancement: Integration of cognitive and neuronal mechanisms’, Biochemical Pharmacology, 78, 658–67.

    Article  PubMed  PubMed Central  Google Scholar 

  • Schacht, J. P., Anton, R. F., & Myrick, H. (2013). ‘Functional neuroimaging studies of alcohol cue reactivity: A quantitative meta-analysis and systematic review’, Addiction Biology, 18, 121–33.

    Article  PubMed  PubMed Central  Google Scholar 

  • Schacht, J. P., Anton, R. F., Randall, P. K., Li, X., Henderson, S., & Myrick, H. (2013). ‘Effects of a GABA-ergic medication combination and initial alcohol withdrawal severity on cue-elicited brain activation among treatment-seeking alcoholics’, Psychopharmacology (Berlin, Germany), 227, 627–37

    Article  Google Scholar 

  • Schacht, J. P., Anton, R. F., Voronin, K. E., Randall, P. K., Li, X., Henderson, S., & Myrick, H. (2012). ‘Interacting effects of naltrexone and OPRM1 and DAT1 variation on the neural response to alcohol cues’, Neuropsychopharmacology, 38, 414–22.

    Article  PubMed  PubMed Central  Google Scholar 

  • Stewart, J. L., Connolly, C. G., May, A. C., Tapert, S. F., Wittmann, M., & Paulus, M. P. (2014). ‘Striatum and insula dysfunction during reinforcement learning differentiates abstinent and relapsed methamphetamine-dependent individuals’, Addiction, 109, 460–71.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sutherland, M. T, Carroll, A. J., Salmeron, B. J., Ross, T. J., Hong, L. E., & Stein, E. A. (2013). ‘Down-regulation of amygdala and insula functional circuits by varenicline and nicotine in abstinent cigarette smokers’, Biological Psychiatry, 74, 538–46.

    Article  PubMed  PubMed Central  Google Scholar 

  • Versace, F., Engelmann, J. M., Robinson, J. D., Jackson, E. R, Green, C. E., Lam, C. Y., … Cinciripini, P. M. (2014). ‘Prequit fMRI responses to pleasant and cigarette cues predict smoking cessation outcome’, Nicotine & Tobacco Research, 16, 697–708.

    Article  Google Scholar 

  • Volkow, N. D., Wang, G. J., Fowler, J. S., & Tomasi, D. (2012). ‘Addiction circuitry in the human brain’, Annual Review of Pharmacology and Toxicology, 52, 321–36.

    Article  PubMed  PubMed Central  Google Scholar 

  • Vollstädt-Klein, S., Loeber, S., Kirsch, M., Bach, P., Richter, A., Buhler, M., … Kiefer, F. (2011). ‘Effects of cue-exposure treatment on neural cue reactivity in alcohol dependence: A randomized trial’, Biological Psychiatry, 69, 1060–6.

    Article  PubMed  Google Scholar 

  • Walter, M., Denier, N., Gerber, H., Schmid, O., Lanz, C., Brenneisen, R., … Borgwardt, S. (2014). ‘Orbitofrontal response to drug-related stimuli after heroin administration’, Addiction Biology.

    Google Scholar 

  • Wang, W., Li, Q., Wang, Y, Tian, J., Yang, W., Li, W., … Liu, J. (2011). ‘Brain fMRI and craving response to heroin-related cues in patients on methadone maintenance treatment’, The American Journal of Drug and Alcohol Abuse, 37, 123–30.

    Article  PubMed  Google Scholar 

  • Wilson, S.J., Sayette, M. A., & Fiez, J. A. (2004). ‘Prefrontal responses to drug cues: A neurocognitive analysis’. Nature Neuroscience, 7, 211–14.

    Article  PubMed  PubMed Central  Google Scholar 

  • Worhunsky P. D., Stevens, M. C., Carroll, K. M., Rounsaville, B. J., Calhoun, V. D., Pearlson, G. D., & Potenza, M. N. (2013). ‘Functional brain networks associated with cognitive control, cocaine dependence, and treatment outcome’, Psychology of Addictive Behaviors, 27, 477–88.

    Article  PubMed  PubMed Central  Google Scholar 

  • Xu, K., Seo, D., Hodgkinson, C., Hu, Y, Goldman, D., & Sinha, R. (2013). ‘A variant on the kappa opioid receptor gene (OPRK1) is associated with stress response and related drug craving, limbic brain activation and cocaine relapse risk’, Translational Psychiatry 3, e292.

    Article  Google Scholar 

  • Young, K. A., Franklin, T. R., Roberts, D. C., Jagannathan, K., Suh, J. J., Wetherill, R. R., … Childress, A. R. (2014). ‘Nipping cue reactivity in the bud: Baclofen prevents limbic activation elicited by subliminal drug cues’, The Journal of Neuroscience, 34, 5038–43.

    Article  PubMed  PubMed Central  Google Scholar 

  • Yücel, M., Lubman, D. I., Harrison, B. J., Fornito, A., Allen, N. B., Wellard, R. M., … Pantelis, C. (2007). ‘A combined spectroscopic and functional MRI investigation of the dorsal anterior cingulate region in opiate addiction’, Molecular Psychiatry, 12, 691–702.

    Article  Google Scholar 

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Authors
  1. Lara A. Ray
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  2. Kelly E. Courtney
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  3. Daniel Roche
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  4. Karen Miotto
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Editor information

Editors and Affiliations

  1. Oregon Health & Science University, USA

    Sarah W. Feldstein Ewing (Associate Professor) (Associate Professor)

  2. University of New Mexico, USA

    Katie Witkiewitz (Associate Professor) (Associate Professor)

  3. Center for Brain Health, University of Texas-Dallas, USA

    Francesca M. Filbey (Associate Professor) (Associate Professor)

Copyright information

© 2015 Lara A. Ray, Kelly E. Courtney, Daniel Roche, and Karen Miotto

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Ray, L.A., Courtney, K.E., Roche, D., Miotto, K. (2015). Neuropsychopharmacology in Addiction Treatment. In: Ewing, S.W.F., Witkiewitz, K., Filbey, F.M. (eds) Neuroimaging and Psychosocial Addiction Treatment. Palgrave Macmillan, London. https://doi.org/10.1057/9781137362650_4

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