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Brain ischemia with Alzheimer phenotype dysregulates Alzheimer’s disease-related proteins

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Abstract

There are evidences for the influence of Alzheimer’s proteins on postischemic brain injury. We present here an overview of the published evidence underpinning the relationships between β-amyloid peptide, hyperphosphorylated tau protein, presenilins, apolipoproteins, secretases and neuronal survival/death decisions after ischemia and development of postischemic dementia. The interactions of above molecules and their influence and contribution to final ischemic brain degeneration resulting in dementia of Alzheimer phenotype are reviewed. Generation and deposition of β-amyloid peptide and tau protein pathology are essential factors involved in Alzheimer’s disease development as well as in postischemic brain dementia. Postischemic injuries demonstrate that ischemia may stimulate pathological amyloid precursor protein processing by upregulation of β- and γ-secretases and therefore are capable of establishing a vicious cycle. Functional postischemic brain recovery is always delayed and incomplete by an injury-related increase in the amount of the neurotoxic C-terminal of amyloid precursor protein and β-amyloid peptide. Finally, we present here the concept that Alzheimer’s proteins can contribute to and/or precipitate postischemic brain neurodegeneration including dementia with Alzheimer’s phenotype.

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  1. Both authors have equal first authorship.

Authors and Affiliations

  1. Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warszawa, Poland

    Marzena Ułamek-Kozioł, Ryszard Pluta & Sławomir Januszewski

  2. Department of Pharmaceutical Botany, Medical University of Lublin, Lublin, Poland

    Anna Bogucka-Kocka

  3. Department of Clinical Genetics, Medical University of Lublin, Lublin, Poland

    Janusz Kocki

  4. Department of Pathophysiology, Medical University of Lublin, Lublin, Poland

    Stanisław J. Czuczwar

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  1. Marzena Ułamek-Kozioł
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  2. Ryszard Pluta
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  3. Anna Bogucka-Kocka
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  4. Sławomir Januszewski
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  5. Janusz Kocki
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  6. Stanisław J. Czuczwar
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Correspondence to Ryszard Pluta or Stanisław J. Czuczwar.

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Ułamek-Kozioł, M., Pluta, R., Bogucka-Kocka, A. et al. Brain ischemia with Alzheimer phenotype dysregulates Alzheimer’s disease-related proteins. Pharmacol. Rep 68, 582–591 (2016). https://doi.org/10.1016/j.pharep.2016.01.006

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