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Cancer Stem Cells Niche Regulation Within the Tumor Microenvironment

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Abstract

Purpose of Review

Several cancer stem cells (CSCs) niches have been identified in the tumor microenvironment. Hence, it is important to review the underlying mechanisms that allow communication between the CSCs and the tumor microenvironment.

Recent Findings

Biofabricated extracellular matrix scaffolds could also be used to study the relationship between the tumor microenvironment and CSCs. Cancer tumor microenvironment harbors cleaved extracellular components that play a role in cancer pathogenesis. Although relatively few of them have been associated with CSCs. Hence, further studies are required to establish their correlation.

Summary

This review highlights the important cascades as well as the factors released by the components of tumor microenvironment. Additionally, their ability to regulate CSCs proliferation, survival, invasion and migration has also been taken into consideration.

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Authors and Affiliations

  1. Center for Disease Mapping and Therapeutic Research, Era University, Uttar Pradesh, Lucknow, 226003, India

    Zainab Siddiqui

  2. Stem Cell Biology Laboratory, National Institute of Immunology, Delhi, India

    Zaffar Equbal

  3. Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO, USA

    Naoshad Muhammad

  4. Department of Ophthalmology, Washington University School of Medicine, St Louis, MO, USA

    Darksha Usmani

  5. Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

    Satya N. Sankhwar

  6. Research Metabolic Unit, Era University, Lucknow, Uttar Pradesh, India

    S. Nishat Fatima Rizvi

  7. Laboratory for Stem Cell & Restorative Neurology, Department of Biotechnology, Era University, Lucknow, Uttar Pradesh, India

    Abdul Naeem

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Siddiqui, Z., Equbal, Z., Muhammad, N. et al. Cancer Stem Cells Niche Regulation Within the Tumor Microenvironment. Curr. Tissue Microenviron. Rep. (2024). https://doi.org/10.1007/s43152-023-00051-0

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