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Microenvironment of Cancer Stem Cells

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Cancer Stem Cell Markers and Related Network Pathways

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1393))

Abstract

Microenvironment of cancer stem cells (CSCs) consists of a variety of cells and inter-cellular matrix and communications of the components. The microenvironment of CSCs maintains the stemness feature of the CSCs. Several cell types which communicate each other via signaling molecules surrounding CSCs are main factors of the CSC microenvironment. A key question is “What kind of information the cells exchange in the CSC microenvironment?” to reveal the microenvironment and CSC features. Components and molecular markers of CSC microenvironment, signaling cross-talks in CSC microenvironment, and targeting CSC microenvironment are focused in this review.

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Acknowledgements

This work was supported by Japan Agency for Medical Research and Development (AMED), Grant Number JP21mk0101216, JP22mk0101216, JSPS KAKENHI Grant Number 21K12133, and Ministry of Health, Labor, and Welfare (MHLW). The author would like to thank all collaborators.

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  1. Division of Risk Assessment, Center for Biological Safety and Research, National Institute of Health Sciences, Kawasaki, 210-9501, Japan

    Shihori Tanabe

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    Shihori Tanabe

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Tanabe, S. (2022). Microenvironment of Cancer Stem Cells. In: Tanabe, S. (eds) Cancer Stem Cell Markers and Related Network Pathways. Advances in Experimental Medicine and Biology, vol 1393. Springer, Cham. https://doi.org/10.1007/978-3-031-12974-2_5

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