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Novel Approaches Used in Ovarian Tissue Transplantation for Fertility Preservation: Focus on Tissue Engineering Approaches and Angiogenesis Capacity

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Abstract

Due to the impact of the modern lifestyle, female infertility has been reduced because of different reasons. For example, in combined chemotherapeutic therapies, a small fraction of cancer survivors has faced different post-complications and side effects such as infertility. Besides, in modern society, delayed age of childbearing has also affected fertility. Nowadays, ovarian tissue cryopreservation and transplantation (OTC/T) is considered one of the appropriate strategies for the restoration of ovarian tissue and bioactivity in patients with the loss of reproductive function. In this regard, several procedures have been considered to improve the efficacy and safety of OTT. Among them, a surgical approach is used to transplant ovaries into the optimal sites, but the existence of ischemic changes and lack of appropriate revascularization can lead to bulk follicular atresia. Besides, the role of OTC/T is limited in women of advanced maternal age undergoing lifesaving chemo-radiation. As a correlate, the development of de novo approaches with efficacious regenerative outcomes is highly welcomed. Tissue engineering shows high therapeutic potentialities to restore fertility in males and females using the combination of biomaterials, cells, and growth factors. Unfortunately, most synthetic and natural materials are at the experimental stage and only the efficacy has been properly evaluated in limited cases. Along with these descriptions, strategies associated with the induction of angiogenesis in transplanted ovaries can diminish the injuries associated with ischemic changes. In this review, the authors tried to summarize recent techniques, especially tissue engineering approaches for improving ovarian function and fertility by focusing on angiogenesis and neovascularization.

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Data Availability

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Abbreviations

Ang:

Angiopoietin

ASCs:

Adipose tissue–derived stem cells

bFGF:

Basic fibroblast growth factor

ECM:

Extracellular matrix

ECs:

Endothelial cells

FGF:

Fibroblast growth factor

GAGs:

Glycosaminoglycans

HA:

Hyaluronic acid

hMG:

Human menopausal gonadotropin

IVF:

In vitro fertilization

IVM:

In vitro maturation

MSCs:

mesenchymal stem cells

OTC:

ovarian tissue cryopreservation

OTT:

ovarian tissue transplantation

PEG:

polyethylene glycol

TE:

tissue engineering

TGF-β:

transforming growth factor-beta

VEGF:

vascular endothelial growth factor

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Acknowledgements

The authors wish to appreciate the personnel of the Department of Anatomical Sciences for their help and guidance.

Funding

The study was supported by a grant from Tabriz University of Medical Sciences (IR.TBZMED.REC.1400.140).

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Authors and Affiliations

  1. Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, 5166714766, Iran

    Melika Izadpanah, Abbas Majdi Seghinsara & Ali Abedelahi

  2. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Reza Rahbarghazi

  3. Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

    Reza Rahbarghazi

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  1. Melika Izadpanah
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  2. Reza Rahbarghazi
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  3. Abbas Majdi Seghinsara
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  4. Ali Abedelahi
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Contributions

Ali Abedelahi and Reza Rahbarghazi supervised the study. Melika Izadpanah and Amirabbas Majdi collected data and prepared the manuscript. And all authors have read and approved the manuscript.

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Correspondence to Ali Abedelahi.

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Izadpanah, M., Rahbarghazi, R., Seghinsara, A.M. et al. Novel Approaches Used in Ovarian Tissue Transplantation for Fertility Preservation: Focus on Tissue Engineering Approaches and Angiogenesis Capacity. Reprod. Sci. 30, 1082–1093 (2023). https://doi.org/10.1007/s43032-022-01048-0

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