Skip to main content

Advertisement

SpringerLink
Log in

A Case Report of Pregabalin Abuse During Pregnancy and Global Developmental Delay in Infants

  • Case Report
  • Published:
SN Comprehensive Clinical Medicine Aims and scope Submit manuscript

Abstract

Pregabalin is a medication licensed for the treatment of epilepsy and anxiety disorders. In addition, pregabalin is increasingly being reported possessing a potential of misuse. Teratogenic effects have been demonstrated in animal models; however, there is a dearth of research relating to potential teratogenic effects in humans. This case highlights the potential role of intrauterine exposure to pregabalin in contributing to Global Developmental Delay in two children.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Availability of Data and Materials

All relevant information to this case report is available in the patient medical chart.

Code Availability

Not applicable.

References

  1. Bian F, Li Z, Offord J, Davis MD, McCormick J, Taylor CP, Walker LC. Calcium channel alpha2-delta type 1 subunit is the major binding protein for pregabalin in neocortex, hippocampus, amygdala, and spinal cord: an ex vivo autoradiographic study in alpha2-delta type 1 genetically modified mice. Brain Res. 2006;1075(1):68–80.

    Article  CAS  Google Scholar 

  2. Bonnet U, Scherbaum N. How addictive are gabapentin and pregabalin? A systematic review. Eur Neuropsychopharmacol. 2017;27(12):1185–215.

    Article  CAS  Google Scholar 

  3. Grosshans M, Lemenager T, Vollmert C, Kaemmerer N, Schreiner R, Mutschler J, ..., Hermann D. Pregabalin abuse among opiate addicted patients. Europ J Clin Pharmacol. 2013;69(12):2021–2025.

  4. McDonald L, Rennie A, Tolmie J, Galloway P, McWilliam R. Investigation of global developmental delay. Arch Dis Child. 2006;91(8):701–5. https://doi.org/10.1136/adc.2005.078147.

    Article  CAS  Google Scholar 

  5. Mostacci B, Poluzzi E, D’Alessandro R, Cocchi G, Tinuper P. Adverse pregnancy outcomes in women exposed to gabapentin and pregabalin: data from a population-based study. J Neurol Neurosurg Psychiatry. 2018;89(2):223–4.

    Article  Google Scholar 

  6. Pontieri FE, Tanda G, Di Chiara G. Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the “shell” as compared with the “core” of the rat nucleus accumbens. Proc Natl Acad Sci. 1995;92(26):12304–8.

    Article  CAS  Google Scholar 

  7. Tassone DM, Boyce E, Guyer J, Nuzum D. Pregabalin: a novel γ-aminobutyric acid analogue in the treatment of neuropathic pain, partial-onset seizures, and anxiety disorders. Clin Ther. 2007;29(1):26–48.

    Article  CAS  Google Scholar 

  8. Winterfeld U, Merlob P, Baud D, Rousson V, Panchaud A, Rothuizen LE, ..., Buclin T. Pregnancy outcome following maternal exposure to pregabalin may call for concern. Neurology. 2016;86(24):2251–2257.

Download references

Author information

Authors and Affiliations

  1. St Vincent’s University Hospital, Dublin, Ireland

    Jahan Zeb Khan

  2. St John of Gods Hospital, Dublin, Ireland

    Emma Clare Fletcher

  3. St Patrick’s University Hospital, Dublin, Ireland

    Aishling Collins

  4. National Drug Treatment Centre, Dublin, Ireland

    Fiona Fenton

Authors
  1. Jahan Zeb Khan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Emma Clare Fletcher
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Aishling Collins
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Fiona Fenton
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

All authors contributed to the case report. Initial case was identified by JK, initial template was also made by JK, formatting and final submission were done by JK. AC wrote abstract and proofread the completed manuscript. EF completed case report and a full proofread of manuscript. FF proofread the manuscript and provided advice about formatting.

Corresponding author

Correspondence to Jahan Zeb Khan.

Ethics declarations

Ethics Approval

The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committee on human experimentation with the Helsinki Declaration of 1975, as revised in 2008. The authors assert that ethical approval for publication of this case report was not required by their local Ethics Committee.

Consent to Participate

A written informed consent was obtained from the patient for participation to this case report.

Consent for Publication

A written informed consent was obtained from the patient for publication of this case report.

Conflict of Interest

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Medicine, Psychiatry, Paediatrics

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (JPG 2076 KB)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Khan, J.Z., Fletcher, E., Collins, A. et al. A Case Report of Pregabalin Abuse During Pregnancy and Global Developmental Delay in Infants. SN Compr. Clin. Med. 4, 44 (2022). https://doi.org/10.1007/s42399-022-01126-z

Download citation

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s42399-022-01126-z

Keywords

Search

Navigation