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Recent Advances in Schiff Base Ruthenium Metal Complexes: Synthesis and Applications

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Abstract

This review concentrates on recent developments in ruthenium Schiff bases, whose steric and electronic characteristics can be manipulated easily by selecting suitable condensing aldehydes or ketones and primary amines, and their metal complexes. Ruthenium metal-based complexes and Schiff base ligands are rapidly becoming conventionally considered for biological applications (antioxidant, anticancer, antimicrobial), in catalysis, in functional materials, in sensors, and as pigments for dyes. Ruthenium complexes exhibit a broad variety of activities concerning simple Schiff base ligands. This may be due to the octahedral bonding of both Ru(II) and Ru(III) complexes, which acquire an extended reservoir of a three-dimensional framework, providing the potential for an elevated degree of site selectivity for binding to their biological targets. This review provides an overview of this field, and intends to highlight both ligand design and synthetic methodology development, as well as significant applications of these metal complexes. In this review, we summarize our work on the development of ruthenium complexes, which was performed over the last few years.

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Abbreviations

SB:

Schiff base

SBL:

Schiff base ligand

p-cym:

Para-cymene

MCF7:

Human breast adenocarcinoma cells

PC3:

Prostate cancer cells

TH:

Transfer hydrogenation

HuH7:

Human hepatocellular carcinoma cells

LoVo:

Human colon adenocarcinoma cells

A549:

Human lung carcinoma cells

16HBE:

Human lung bronchial epithelium cancer cells

WI38:

Human lung fibroblast cancer cells

HeLa:

Human cervical carcinoma cells

SW620:

Metastatic colorectal adenocarcinoma cells

phen:

1,10-Phenanthroline

bipy:

Bipyridine

CT-DNA:

Calf thymus DNA

CyPen:

Cyclopentyl

CyHex:

Cyclohexyl

CyHep:

Cycloheptyl

CyOct:

Cyclooctyl

HSA:

Human serum albumin

HepG2:

Human hepatocellular cancer cells

ER:

Endoplasmic reticulum

HFHC:

High-fat high carbohydrate

PD:

Diet-induced pre-diabetic rats

ppym:

Pyrene-appended polypyridyl

ZR-75-30:

Human breast cancer cells

bz:

Benzene

MCF-7CR:

Human breast adenocarcinoma cells

MCF-10A:

Non-tumorigenic human breast cells

Et3N:

Triethylamine

TOF:

Turnover frequency

TON:

Turnover numbers

phn:

1,2-Phenyldiamine

en:

1,2-Ethanediamine

BGC823:

Human gastric cancer cells

SGC7901:

Human gastric cancer cells

adpa:

4-(4-Aminophenyl) diazenyl-N-(pyridine-2-ylmethylene aniline)

HCC70:

Human breast carcinoma cells

EJ28:

Human bladder cancer cells

TK10:

Human renal cancer cells

UACC62:

Human melanoma cancer cells

DMF:

Dimethylformamide

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  1. Department of Chemistry, National Institute of Technology, Silchar, Assam, India

    Anmol Singh & Pranjit Barman

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Singh, A., Barman, P. Recent Advances in Schiff Base Ruthenium Metal Complexes: Synthesis and Applications. Top Curr Chem (Z) 379, 29 (2021). https://doi.org/10.1007/s41061-021-00342-w

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