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Presentation of hypoparathyroidism in Italy: a nationwide register-based study

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Abstract

Purpose

We sought to assess the clinical presentation of hypoparathyroidism (HypoPT) in Italy.

Methods

We performed a nationwide study retrieving data from the hospital discharge ICD-9 codes database of the Italian Health Ministry, from 2007 through 2017. The codes corresponding to diagnosis of cardiovascular disease, cancer, infection, renal failure, psychiatric disease, upper airway tract infection and pneumonia, seizures, nephrolithiasis, cognitive impairment, cerebral calcifications, skin disorders, fracture, and cataract were retrieved when associated with the diagnosis of HypoPT (252.1). We excluded codes corresponding to diagnoses of cancer of the neck region. In-hospital mortality rate was calculated. We retrieved the same data from an age- and sex-matched non-HypoPT control population.

Results

Fourteen thousand five hundred seventy-nine hospitalizations for HypoPT and controls were analyzed. Hospitalization for cardiovascular disease, cancer, infection, renal failure, seizures, nephrolithiasis, cerebral calcifications (p < 0.0001), and cognitive impairment (p < 0.05) were more common in HypoPT compared to controls. Mean age of HypoPT with cardiovascular disease, cancer, and renal failure was younger compared to controls (p < 0.0001). The OR of hospitalization for cardiovascular disease, cancer, renal failure, seizures (OR 2, 40, 48  and 1.6, respectively), and nephrolithiasis (OR 1.6) were significant in HypoPT compared to non-HypoPT. The OR of hospitalization for infection and cognitive impairment were significant only in HypoPT women (OR 1.3 and 2.3, respectively). In-hospital mortality rate was lower in HypoPT vs controls (0.5% and 3.7%; p < 0.0001).

Conclusion

Hospitalizations for cardiovascular disease, cancer, and renal failure are more prevalent and occur at a younger age in HypoPT vs non-HypoPT. Hospitalizations for seizures and nephrolithiasis are frequent in HypoPT; those for infection and cognitive impairment are more common in HypoPT women.

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Data availability

The dataset generated during the current study are available from corresponding author on reasonable request.

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Acknowledgements

We wish to thank the Italian Health Ministry for retrieval of data from the National database

Funding

No funding was received for conducting this study.

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Authors and Affiliations

  1. Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy

    C. Cipriani, J. Pepe, L. Colangelo, M. Cilli & S. Minisola

  2. Faculty of Economics, UNINT University, Via Cristoforo Colombo 200, 00147, Rome, Italy

    L. Nieddu

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  1. C. Cipriani
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  2. J. Pepe
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  3. L. Colangelo
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Contributions

CC contributed to study design, data collection and analysis, drafting and revision of the manuscript; JP, LC, MC, and LN contributed to data analysis and revision of the manuscript; and SM contributed to study design, data collection, and revision of the manuscript.

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Correspondence to C. Cipriani.

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Conflict of interest

CC served as speaker for Abiogen and in advisory board of IBSA. SM served as speaker for Abiogen, Bruno Farmaceutici, Diasorin, Kyowa Kirin, UCB. He also served in advisory board of Eli Lilly, Kyowa Kirin, UCB. The other authors have no relevant financial or non-financial interests to disclose.

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Cipriani, C., Pepe, J., Colangelo, L. et al. Presentation of hypoparathyroidism in Italy: a nationwide register-based study. J Endocrinol Invest (2024). https://doi.org/10.1007/s40618-023-02271-5

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