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HypoparaNet: A Database of Chronic Hypoparathyroidism Based on Expert Medical-Surgical Centers in Italy

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Abstract

Hypoparathyroidism is a rare disease characterized by low serum calcium levels and absent or deficient parathyroid hormone level. Regarding the epidemiology of chronic hypoparathyroidism, there are limited data in Italy and worldwide. Therefore, the purpose of this study was to build a unique database of patients with chronic hypoparathyroidism, derived from the databases of 16 referral centers for endocrinological diseases, affiliated with the Italian Society of Endocrinology, and four centers for endocrine surgery with expertise in hypoparathyroidism, to conduct an epidemiological analysis of chronic hypoparathyroidism in Italy. The study was approved by the Institutional Review Board. A total of 537 patients with chronic hypoparathyroidism were identified. The leading etiology was represented by postsurgical hypoparathyroidism (67.6%), followed by idiopathic hypoparathyroidism (14.6%), syndromic forms of genetic hypoparathyroidism (11%), forms of defective PTH action (5.2%), non-syndromic forms of genetic hypoparathyroidism (0.9%), and, finally, other forms of acquired hypoparathyroidism, due to infiltrative diseases, copper or iron overload, or ionizing radiation exposure (0.7%). This study represents one of the first large-scale epidemiological assessments of chronic hypoparathyroidism based on data collected at medical and/or surgical centers with expertise in hypoparathyroidism in Italy. Although the study presents some limitations, it introduces the possibility of a large-scale national survey, with the final aim of defining not only the prevalence of chronic hypoparathyroidism in Italy, but also standards for clinical and therapeutic approaches.

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Acknowledgements

SHIRE, pharmaceutical company.

Data Availability

All data analyzed during this study are included in this published article.

Funding

This study was funded by Shire, a pharmaceutical company.

Author information

Authors and Affiliations

  1. Bone Metabolic Diseases Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy

    Gemma Marcucci, Luisella Cianferotti, Simone Parri & Maria Luisa Brandi

  2. Division of Endocrinology, S. Orsola-Malpighi Hospital, University Alma Mater Studiorum of Bologna, Bologna, Italy

    Paola Altieri & Renato Pasquali

  3. Oncological Endocrinology Unit, Department of Medical Sciences, University of Turin, Turin, Italy

    Emanuela Arvat & Maria Teresa Samà

  4. Department of Clinical and Experimental Medicine, University of Messina School of Medicine, Messina, Italy

    Salvatore Benvenga & Rosaria Maddalena Ruggeri

  5. Department of Medicine (DIMED)-Endocrinology, University of Padua, Padua, Italy

    Corrado Betterle, Marco Boscaro & Valentina Camozzi

  6. Section of Endocrinology & Internal Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, Italy

    Marta Bondanelli, Ettore degli Uberti & Maria Chiara Zatelli

  7. Internal Medicine Hospital, Monsignor Dimiccoli, Barletta, Italy

    Grazia Maria Centaro

  8. Endocrine Unit 2, University Hospital of Pisa, Pisa, Italy

    Filomena Cetani

  9. Endocrinology Unit, Fondazione IRCCS Cà Granada Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

    Iacopo Chiodini, Giovanna Mantovani & Serena Palmieri

  10. Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy

    Anna Ciampolillo & Francesco Giorgino

  11. Department of Clinical Medicine and Surgery, Federico II di Naples University, Naples, Italy

    Annamaria Colao

  12. Endocrinology Unit, Department of Biomedical Sciences for Health, University of Milan, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy

    Sabrina Corbetta

  13. Endocrinology and Diabetology Unit UOSD, Hospital USL 11, Empoli, Italy

    Maria Laura De Feo, Valeria Giuliani & Valentina Piccini

  14. Thyroid and Parathyroid Surgery Unit, Istituto Nazionale per lo studio e la cura dei tumori “Fondazione G. Pascale” - IRCCS, Naples, Italy

    Antongiulio Faggiano

  15. Department Experimental Medicine, Section Medical Pathophysiology, Endocrinology and Nutrition, University “Sapienza” of Rome, Rome, Italy

    Rachele Fornari, Andrea Lenzi & Elisabetta Romagnoli

  16. Department of Surgery, University Hospital of Tor Vergata, Rome, Italy

    Achille Lucio Gaspari

  17. Endocrine Surgery Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy

    Maurizio Iacobone & Giuseppe Tomaino

  18. Endocrine Surgery UOC, University College of Catanzaro/Policlinico universitario, Catanzaro, Italy

    Nadia Innaro

  19. Unit of Endocrinology and Metabolic Diseases, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy

    Olga Lamacchia

  20. Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy

    Claudio Marcocci

  21. Bone Metabolic Diseases Unit, University Hospital of Florence, Florence, Italy

    Laura Masi

  22. Unit of Endocrinology, Department of Movement, Human and Health Sciences, University “Foro Italico” of Rome, Rome, Italy

    Silvia Migliaccio

  23. Department of Surgery and Translational Medicine, University of Florence, Florence, Italy

    Giuliano Perigli

  24. Department of Surgical Sciences, Catholic University “Our Lady of Good Counsel”, Tirana, Albania

    Francesco Rulli

  25. Accademia Peloritana dei Pericolanti, University of Messina, Messina, Italy

    Francesco Trimarchi

Authors
  1. Gemma Marcucci
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  2. Luisella Cianferotti
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  3. Simone Parri
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  4. Paola Altieri
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  5. Emanuela Arvat
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  6. Salvatore Benvenga
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  7. Corrado Betterle
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  8. Marta Bondanelli
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  9. Marco Boscaro
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  10. Valentina Camozzi
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  11. Grazia Maria Centaro
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  12. Filomena Cetani
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  13. Iacopo Chiodini
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  14. Anna Ciampolillo
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  15. Annamaria Colao
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  16. Sabrina Corbetta
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  17. Maria Laura De Feo
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  18. Ettore degli Uberti
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  19. Antongiulio Faggiano
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  20. Rachele Fornari
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  21. Achille Lucio Gaspari
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  22. Francesco Giorgino
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  23. Valeria Giuliani
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  24. Maurizio Iacobone
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  25. Nadia Innaro
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  26. Olga Lamacchia
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  27. Andrea Lenzi
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  28. Giovanna Mantovani
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  29. Claudio Marcocci
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  30. Laura Masi
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  31. Silvia Migliaccio
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  32. Serena Palmieri
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  33. Renato Pasquali
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  34. Giuliano Perigli
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  35. Valentina Piccini
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  36. Elisabetta Romagnoli
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  37. Rosaria Maddalena Ruggeri
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  38. Francesco Rulli
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  39. Maria Teresa Samà
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  40. Giuseppe Tomaino
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  41. Francesco Trimarchi
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  42. Maria Chiara Zatelli
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  43. Maria Luisa Brandi
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Contributions

MLB was the coordinator of the project and designed the study. All authors contributed to the collection of clinical data, and the paper was drafted by GM, LC and MLB. SP was responsible for statistical analysis of the data. All authors revised the paper critically for intellectual content and approved the final version. All authors agree to be accountable for the work and to ensure that any questions relating to the accuracy and integrity of the paper are investigated and properly resolved.

Corresponding author

Correspondence to Maria Luisa Brandi.

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Conflict of interest

G. Mantovani: member of advisory boards for Shire; C. Marcocci: consultant for Shire Italia. M.L. Brandi: is a consultant for Alexion, Bruno Farmaceutici, Shire, Servier, Kyowa Kirin; academic grants and/or speaker: Abiogen, Alexion, Amgen, Bruno Farmaceutici, Eli Lilly, Kyowa Kirin, MSD, NPS, Servier, Shire, SPA; she has received honoraria from: Amgen, Bruno Farmaceutici, Kyowa Kirin. The other authors declare that they have no competing interests that could be perceived as prejudicing the impartiality of the research reported.

Consent for Publication

The consent to the publication of the data was obtained.

Ethical Approval

The study was approved by the Institutional Review Board (Comitato Etico Area Vasta Centro, AUOC, Florence, Italy); Number: 10641_oss.

Human and Animal Rights and Informed Consent

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.  For this type of study formal consent is not required.

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Marcucci, G., Cianferotti, L., Parri, S. et al. HypoparaNet: A Database of Chronic Hypoparathyroidism Based on Expert Medical-Surgical Centers in Italy. Calcif Tissue Int 103, 151–163 (2018). https://doi.org/10.1007/s00223-018-0411-7

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  • DOI: https://doi.org/10.1007/s00223-018-0411-7

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