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Malnutrition, assessed by the Global Leadership Initiative on Malnutrition (GLIM) criteria but not by the mini nutritional assessment (MNA), predicts the incidence of sarcopenia over a 5-year period in the SarcoPhAge cohort

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A Correction to this article was published on 13 July 2021

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Abstract

Background

The capacity of malnutrition screening to predict the onset of sarcopenia is unknown.

Aim

Our first objective is to explore the association between the screening of malnutrition and the incidence of sarcopenia and then, to assess the added value of the diagnosis of malnutrition to predict sarcopenia over a 5-year follow-up.

Methods

Malnutrition was screened at baseline according to the MNA short-form (MNA-SF) and long-form (MNA-LF) and was diagnosed by the GLIM definition. Sarcopenia was defined using the European Working Group on Sarcopenia in Older People (EWGSOP2) criteria. Kaplan–Meier analysis and adjusted Cox regression were performed to explore the association between nutritional status and the incidence of sarcopenia.

Results

A total of 418 participants were analyzed (median age 71.7 years (67.7 – 76.8), 60% women) for our first objective. Among them, 64 (15.3%) became sarcopenic during the follow-up period. In the adjusted model, the incidence of sarcopenia was nonsignificantly associated with the risk of malnutrition for both forms of the MNA (MNA-SF: HR of 1.68 (95% CI 0.95 – 2.99); MNA-LF: HR of 1.67 (95% CI 0.86 – 3.26)). However, among the 337 participants for which a GLIM assessment was possible and in which 46 participants became sarcopenic, malnourished subjects had a higher risk than well-nourished participants of developing sarcopenia after 5 years, with an adjusted HR of 3.19 (95% CI 1.56 – 6.50).

Conclusion

A full diagnosis of malnutrition seems more useful than a simple malnutrition screening to predict the incidence of sarcopenia over 5 years.

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Availability of data and material

The datasets generated and/or analyzed in the current study are not publicly available due to GDPR policies and restrictions because the information could compromise the privacy of the participants. However, the data are available from the corresponding author on reasonable request.

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Funding

M.L. is supported by a fellowship from the FNRS (Fonds National de la Recherche Scientifique de Belgium—FRSFNRS—http://www.frs-fnrs.be).

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Authors and Affiliations

  1. WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Division of Public Health, Epidemiology and Health Economics, University of Liège, CHU—Sart Tilman, Quartier Hôpital, Avenue Hippocrate 13 (Bât. B23), 4000, Liège, Belgium

    Laetitia Lengelé, Olivier Bruyère, Charlotte Beaudart, Jean-Yves Reginster & Médéa Locquet

  2. Department of Sport Rehabilitation Sciences, University of Liège, 4000, Liège, Belgium

    Olivier Bruyère

  3. Physical, Rehabilitation Medicine and Sports Traumatology, University Hospital of Liège, SportS2, 4000, Liège, Belgium

    Olivier Bruyère

  4. Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia

    Jean-Yves Reginster

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  1. Laetitia Lengelé
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Contributions

Conceptualization, O.B., C.B., and J.-Y.R.; methodology, L.L., O.B., and M.L.; software, L.L.; validation, L.L., O.B., M.L., C.B. and J.-Y.R.; formal analysis, L.L.; investigation, L.L., M.L. and C.B.; resources, O.B. and J.-Y.R.; data curation, L.L., M.L., and C.B.; writing—original draft preparation, L.L.; writing—review and editing, L.L., M.L., O.B., and C.B.; supervision, O.B. and J.-Y.R. All authors have read and agreed to the published version of the manuscript.

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Correspondence to Laetitia Lengelé.

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The guidelines of the Declaration of Helsinki were followed, and the present study was approved by the ethics committee of the University of Liege Teaching Hospital (reference 2012/277), with two amendments in 2015 and 2018.

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In the original publication of the article was wrongly published. The correct title is “Malnutrition, assessed by the Global Leadership Initiative on Malnutrition (GLIM) criteria but not by the mini nutritional assessment (MNA), predicts the incidence of sarcopenia over a 5-year period in the SarcoPhAge cohort".

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Lengelé, L., Bruyère, O., Beaudart, C. et al. Malnutrition, assessed by the Global Leadership Initiative on Malnutrition (GLIM) criteria but not by the mini nutritional assessment (MNA), predicts the incidence of sarcopenia over a 5-year period in the SarcoPhAge cohort. Aging Clin Exp Res 33, 1507–1517 (2021). https://doi.org/10.1007/s40520-021-01880-5

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