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Synergism of SPECT/CT and portable gamma cameras for intraoperative sentinel lymph node biopsy in melanoma, breast cancer, and other malignancies

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Abstract

The anatomical localization of sentinel lymph nodes or tracer avid lesions with preoperative SPECT/CT provides imaging for accurate radioguided interventions. Surgeons can use the provided anatomic landmarks to retrieve the detected target lesions during operation. This three-dimensional roadmap generated by this hybrid molecular modality has helped to transform the initial paradigm to one of “see, open and recognize”. The approach has been reinforced with the growing synergy of preoperative SPECT/CT with intraoperative portable imaging devices. Small portable gamma cameras have been incorporated in radioguided surgery by providing real-time imaging with a larger field of detection than a gamma probe can cover. Moreover, they provide visual assistance in localization and verification of resection of the targeted tissue, and they are able to reproduce SPECT/CT findings in the intraoperative localization of sentinel nodes in complex or difficult anatomic areas like the head and neck. Moreover, to overcome the lack of anatomic information, the prototypes of a new generation of fused optical/scintigraphic imaging have been recently developed.

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Acknowledgments

We thank Marianne Valdes Olmos for accurately review and improve the language editing.

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Authors and Affiliations

  1. Nuclear Medicine Department, Hospital Clínic Barcelona, Villarroel 170, 08036, Barcelona, Spain

    Sergi Vidal-Sicart

  2. Institut d’Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain

    Sergi Vidal-Sicart

  3. Nuclear Medicine Section and Interventional Molecular Imaging Laboratory, Department of Radiology C2-S, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, The Netherlands

    Renato A. Valdés Olmos

  4. Diagnostic Oncology Division, Nuclear Medicine Department, Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Plesmanlaan 126, 1066 CX, Amsterdam, The Netherlands

    Renato A. Valdés Olmos

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  1. Sergi Vidal-Sicart
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Correspondence to Sergi Vidal-Sicart.

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The authors (SVS and RAVO) have no conflicts of interest.

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Not applicable—the manuscript is a review article. Original research cited in the article and performed by one of the authors were approved by local Ethics Committee, and all patients signed written informed consent forms.

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Vidal-Sicart, S., Valdés Olmos, R.A. Synergism of SPECT/CT and portable gamma cameras for intraoperative sentinel lymph node biopsy in melanoma, breast cancer, and other malignancies. Clin Transl Imaging 4, 313–327 (2016). https://doi.org/10.1007/s40336-016-0181-z

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  • DOI: https://doi.org/10.1007/s40336-016-0181-z

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