Skip to main content

Advertisement

Log in

Sentinel node in breast cancer procedural guidelines

  • Guidelines
  • Published:
European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Content

Procedure guidelines for scintigraphic detection of sentinel node in breast cancer are presented.

Authors

The paper was written by several experts in this field on behalf of the European Association of Nuclear Medicine Oncology and Dosimetry committees and approved by the Executive Committee.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Keshtgar MRS, Ell PJ. Sentinel lymph node detection and imaging. Eur J Nucl Med 1999;26:57–67.

    Article  PubMed  CAS  Google Scholar 

  2. Veronesi U, Paganelli G, Viale G, Luini A, Zurrida S, Galimberti V, et al. A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer. N Engl J Med 2003;349:546–53.

    Article  PubMed  Google Scholar 

  3. Veronesi U, Paganelli G, Viale G, Luini A, Zurrida S, Galimberti V, et al. Sentinel-lymph-node biopsy as a staging procedure in breast cancer: update of a randomized controlled study. Lancet Oncol 2006;7:983–90.

    Article  PubMed  Google Scholar 

  4. De Cicco C, Cremonesi M, Luini A, Bartolomei M, Grana C, Prisco G, et al. Lymphoscintigraphy and radioguided biopsy of the sentinel axillary node in breast cancer. J Nucl Med 1998; 39:2080–4.

    PubMed  Google Scholar 

  5. Amersi F, Hansen NM. The benefits and limitations of sentinel lymph node biopsy. Curr Treat Options Oncol 2006;7:141–51.

    Article  PubMed  Google Scholar 

  6. Keleher A, Wendt R 3rd, Delpassand E, Stachowiak AM, Kuerer HM. The safety of lymphatic mapping in pregnant breast cancer patients using Tc-99m sulphur colloid. Breast J 2004;10:492–5.

    Article  PubMed  Google Scholar 

  7. Morita ET, Chang J, Leong SP. Principles and controversies in lymphoscintigraphy with emphasis on breast cancer. Surg Clin North Am 2000;80:1721–39.

    Article  PubMed  CAS  Google Scholar 

  8. Gentilini O, Cremonesi M, Trifirò G, Ferrari M, Baio SM, Caracciolo M, et al. Safety of sentinel node biopsy in pregnant patients with breast cancer. Ann Oncol 2004;15:1348–51.

    Article  PubMed  CAS  Google Scholar 

  9. Krag D, Weaver D, Ashikaga T, Moffat F, Klimberg VS, Shriver C, et al. The sentinel node in breast cancer—a multi-center validation study. N Engl J Med 1998;339:941–6.

    Article  PubMed  CAS  Google Scholar 

  10. Lyman GH, Giuliano AE, Somerfield MR, Benson AB 3rd, Bodurka DC, Burstein HJ, et al. American Society of Clinical Oncology. American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer. J Clin Oncol 2005;23:7703–20.

    Article  PubMed  Google Scholar 

  11. NEMA. NU 1 2001 Performance Measurements of Scintillation Cameras. Rosslyn: National Electrotechnical Manufacturers Association; 2001 (http://www.nema.org/stds/nu1.cfm).

  12. IEC. IEC/TR 61948-2 Ed. 1.0 en:2001 Nuclear medicine instrumentation—routine tests—part 2: scintillation cameras and single photon emission computed tomography imaging. Geneva: International Electrotechnical Commission; 2001.

  13. NEMA. NU 3 2004 Performance measurements and quality control guidelines for non-imaging intraoperative gamma probes. Rosslyn: National Electrotechnical Manufacturers Association; 2004 ( http://www.nema.org/stds/nu3.cfm ).

  14. Mariani G, Moresco I, Viale G, Villa G, Bagnasco M, Canavese G, et al. Radioguided sentinel lymph node biopsy in breast cancer surgery. J Nucl Med 2001;42:1198–215.

    PubMed  CAS  Google Scholar 

  15. Bourgeois P. Scintigraphic investigations of the lymphatic system: the influence of injected volume and quantity of labeled colloidal tracer. J Nucl Med 2007;48:693–5.

    Article  PubMed  Google Scholar 

  16. Veronesi U, Paganelli G, Galimberti V, Viale G, Zurrida S, Bedoni M, et al. Sentinel node biopsy to avoid axillary dissection in breast cancer patients with clinically negative lymph-nodes. Lancet 1997;349:1864–7.

    Article  PubMed  CAS  Google Scholar 

  17. Law M, Cheng KC, Wu PM, Ho WY, Chow LW. Patient effective dose from sentinel lymph node lymphoscintigraphy in breast cancer: a study using a female humanoid phantom and thermoluminescent dosimeters. Br J Radiol 2003;76:818–23.

    Article  PubMed  CAS  Google Scholar 

  18. Waddington WA, Keshtgar MRS, Taylor I, Lakhani SR, Short MD, Ell PJ. Radiation safety of the sentinel node technique in breast cancer. Eur J Nucl Med 2000;27:377–91.

    Article  PubMed  CAS  Google Scholar 

  19. Cremonesi M, Ferrari M, Sacco E, Rossi A, De Cicco C, Leonardi L, et al. Radiation protection in radioguided surgery of breast cancer. Nucl Med Commun 1999;20:919–24.

    PubMed  CAS  Google Scholar 

  20. Pijpers R, Meijer S, Hoekstra OS, Collet GJ, Comans EF, Boom RP, et al. Impact of lymphoscintigraphy on sentinel node identification with technetium-99m-colloid albumin in breast cancer. J Nucl Med 1997;38:366–8.

    CAS  Google Scholar 

  21. Pelosi E, Bello M, Griors M, Ala A, Giani R, Bussone R, et al. Sentinel lymph node detection in patients with early-stage breast cancer: comparison of periareolar and subdermal/peritumoral injection techniques. J Nucl Med 2004;45:220–5.

    PubMed  Google Scholar 

  22. Chakera AH, Friis E, Hesse U, Al-Suliman N, Zerahn B, Hesse B. Factors of importance for scintigraphic non-visualization of sentinel nodes in breast cancer. Eur J Nucl Med Mol Imaging 2005;32:286–93.

    Article  PubMed  CAS  Google Scholar 

  23. Zanzonico P, Heller S. The intraoperative gamma probe: basic principles and choices available. Semin Nucl Med 2000;1:33–48.

    Article  Google Scholar 

  24. International Electrotechnical Commission. Medical electrical equipment—part 1: general requirements for safety. IEC 60101-1. (1988-12). Geneva: IEC; 1988.

  25. Paganelli G, Galimberti V, Trifirò G, Travaini L, De Cicco C, Mazzarol G, et al. Internal mammary node lymphoscintigraphy and biopsy in breast cancer. Q J Nucl Med 2002;46:138–44.

    PubMed  CAS  Google Scholar 

  26. Clarke D, Khoni N, Mansel ER. Sentinel node biopsy in breast cancer. ALMANAC trial. World J Surg 2001;25:819–22.

    Article  PubMed  CAS  Google Scholar 

  27. Luini A, Galimberti V, Gatti G, Arnone P, Vento AR, Trifiro G, et al. The sentinel node biopsy after previous breast surgery; preliminary results on 543 patients treated at EIO. Breast Cancer Res Treat 2005;89:159–63.

    Article  PubMed  Google Scholar 

  28. Schwartz GF, Meltzer AJ. Accuracy of sentinel node biopsy following neoadjuvant (induction) chemotherapy for carcinoma of the breast. Breast J 2003;9:374–9.

    Article  PubMed  Google Scholar 

  29. Kumar R, Jana S, Heiba SI, Dakhel M, Axelrod D, Siegel B, et al. Retrospective analysis of sentinel node localization in multifocal multicentric, palpable, or non palpable breast cancer. J Nucl Med 2003;44:7–10.

    PubMed  Google Scholar 

  30. Knauer M, Konstantiniuk P, Haid A, Wenzl E, Riegler-Keil M, Postlberger S, et al. Multicentric breast cancer: a new indication for sentinel node biopsy—a multi institutional validation study. J Clin Oncol 2006;24:3374–80.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Consortia

Corresponding author

Correspondence to Arturo Chiti.

Additional information

Disclaimer: The European Association of Nuclear Medicine has written and approved guidelines to promote the cost-effective use of high-quality nuclear medicine procedures. These generic recommendations cannot be rigidly applied to all patients in all practice settings. The guidelines should not be deemed inclusive of all proper procedures or exclusive of other procedures reasonably directed to obtaining the same results. Advances in medicine occur at a rapid rate. The date of a guideline should always be considered in determining its current applicability. All authors declare they have no conflict of interest.

An Editorial commentary on this paper is available at http://dx.doi.org/10.1007/s00259-007-0616-x-.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Buscombe, J., Paganelli, G., Burak, Z.E. et al. Sentinel node in breast cancer procedural guidelines. Eur J Nucl Med Mol Imaging 34, 2154–2159 (2007). https://doi.org/10.1007/s00259-007-0614-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00259-007-0614-z

Keywords

Navigation