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A new porous cationic metal–organic framework: selective sorption of organic dyes and treatment on neural stem cells during spinal cord injury treatment

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Abstract

A novel metal–organic framework containing Co(II) of {(Me2NH2)4[Co12(OH)4(abtc)6 (H2O)12]·14H2O}n (1) has been synthesized via Co(NO3)2·6H2O to react with the 3,3′,5,5′-azobenzenetetracarboxylic acid (H4abtc) ligand under solvothermal conditions. Furthermore, methylene blue (MB) can easily replace free cations; after half a day, more than 90% of the MB (10−5 M) is absorbed selectively, and it makes the title compound become a good medium for the separation and adsorption of the dye. In biological section, the enhancement activity of the compound on the nerve growth factor for the spinal cord injury treatment was evaluated. The relative gene expression of trkA receptor was measured with reverse transcription polymerase chain reaction. In addition to this, the activation of PI3K/Akt signaling pathway in neural stem cells after treated by compound was evaluated with western blot. The results of potential binding models were predicted by molecular docking, and the binding poses provided possible binding mechanisms of the functional groups of the complex to the TRKA protein.

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Authors and Affiliations

  1. Department of Orthopaedics, Linyi Central Hospital, Linyi, Shandong, China

    Cong Cao & Zai-Qing Zhang

  2. Department of General Practice, Linyi Central Hospital, Linyi, Shandong, China

    Zhi-Zhang Li

  3. Department of Orthopaedics, The Affiliated Hospital of Putian University, Putian, Fujian, China

    Xuan-Huang Chen

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  1. Cong Cao
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  2. Zhi-Zhang Li
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  3. Zai-Qing Zhang
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Correspondence to Xuan-Huang Chen.

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Cao, C., Li, ZZ., Zhang, ZQ. et al. A new porous cationic metal–organic framework: selective sorption of organic dyes and treatment on neural stem cells during spinal cord injury treatment. J IRAN CHEM SOC 17, 2933–2942 (2020). https://doi.org/10.1007/s13738-020-01969-0

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  • DOI: https://doi.org/10.1007/s13738-020-01969-0

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