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A New Co(II)-Based Coordination Polymer for Photocatalytic Degradation of Organic Dyes and Protective Effect on Spinal Cord Injury by Increasing trka Receptor Gene Expression on the NSCs

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Abstract

By using a light-harvesting organic ligand tris(4-(1H-imidazol-1-yl)phenyl)amine (TIPA), a new Co(II)-based coordination polymer (1) with the chemical formula of [Co2(TIPA)2(Tz)][Co(TIPA)(NO3)(H2O)]·4NO3·2DMA·2H2O has been generated via reaction of Co(NO3)2·6H2O with the tetrazole (Tz) ligands and TIPA in water and DMA mixed solvent under the conditions of solvothermal. Significantly, complex 1 is capable of photodegradation of the organic dyes with the existence of hydrogen peroxide and ultraviolet irradiation (λ = 254 nm). Furthermore, the mechanism of photocatalytic degradation of the organic dyes is studied. In biological research, we aimed to develop the compound which could increase the protective effect of NGF on NSCs during the treatment of spinal cord injury. The RT-PCR was performed to evaluate the trka receptor gene expression on the NSCs. The western was used to evaluate the activation for signaling pathway of PI3K/Akt in NSCs after compound treatment.

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Acknowlegdements

This study was supported by the Fundamental Research Funds for the Central Universities (2042017kf0139), Innovative Seed Funds of Medical College of Wuhan University (TFZZ2018027), Natural Science Foundation of Hubei Province (2019CFB457) and Wuhan Medical Research Project (Youth Project) (WZ19Q02).

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Author notes

  1. Ming Deng and Jinju Xue contributed equally to this work.

Authors and Affiliations

  1. Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei, China

    Ming Deng, Yan Zhou, Zhong-Hui Chen & Yong-Gang Ma

  2. Department of Geriatrics, Haikou People’s Hospital, Haikou, Hainan, China

    Jinju Xue

  3. Department of Chinese Traditional Medicine, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan, Hubei, China

    Ping Xie

  4. Department of Orthopedics, Hainan Provincial People’s Hospital, Haikou, Hainan, China

    Hui Huang

  5. Department of Radiation Oncology, The First of Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

    Jun-Qi Liu

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  1. Ming Deng
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Correspondence to Yong-Gang Ma.

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Deng, M., Xue, J., Xie, P. et al. A New Co(II)-Based Coordination Polymer for Photocatalytic Degradation of Organic Dyes and Protective Effect on Spinal Cord Injury by Increasing trka Receptor Gene Expression on the NSCs. J Inorg Organomet Polym 30, 3213–3220 (2020). https://doi.org/10.1007/s10904-020-01480-2

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