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Synthesis, characterization, cytotoxic activity and DNA-binding studies of cobalt (II) mixed-ligand complex containing pyridine-2,6-dicarboxylate ion and 2-aminopyrimidine

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Abstract

Treatment of pyridine-2,6-dicarboxylic acid and 2-aminopyrimidine with Co(NO3)2∙6H2O under hydrothermal conditions led to a new Co (II) complex [Co(amp)(pydc)(H2O)2]∙H2O (1), which was characterized by infrared spectroscopy, elemental analysis as well as X-ray diffraction studies. The DNA-binding behavior of the complex has been studied by UV–Vis absorption and fluorescence spectroscopic titration, viscosity measurements, thermal denaturation and circular dichroism (CD). The experimental results indicated that Co (II) complex was bound to DNA by an intercalative mode. The intrinsic binding constant of Co (II) complex with DNA was (3.80 ± 0.02) × 104 M−1. The biological effects of the Co (II) complex were also studied by MTT assay in MCF-7 and HT-29 cancer cell lines. Treatment of MCF-7 and HT-29 cells with Co (II) complex resulted in a concentration-dependent cell growth inhibition.

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Acknowledgments

We gratefully acknowledge the support from Qom University, Payam Noor University and Yazd branch Islamic Azad University.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, University of Qom, Qom, Iran

    Maryam Bordbar

  2. Department of Chemistry, Yazd Branch, Islamic Azad University, Yazd, Iran

    Masoumeh Tabatabaee & Majid Alizadeh-Nouqi

  3. Department of Chemistry, Isfahan University of Technology, Isfahan, 84156/83111, Iran

    Zohreh Mehri-Lighvan

  4. Department of Chemistry, Shahid Beheshti University, Tehran, Iran

    Hamid Reza Khavasi

  5. Department of Chemistry, Faculty of Science, Payam Noor University, Tehran, Iran

    Ali YeganehFaal

  6. Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran

    Faranak Fallahian & Masoumeh Dolati

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  1. Maryam Bordbar
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Correspondence to Masoumeh Tabatabaee.

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Bordbar, M., Tabatabaee, M., Alizadeh-Nouqi, M. et al. Synthesis, characterization, cytotoxic activity and DNA-binding studies of cobalt (II) mixed-ligand complex containing pyridine-2,6-dicarboxylate ion and 2-aminopyrimidine. J IRAN CHEM SOC 13, 1125–1132 (2016). https://doi.org/10.1007/s13738-016-0826-x

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  • DOI: https://doi.org/10.1007/s13738-016-0826-x

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