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The roles of microRNAs related with progression and metastasis in human cancers

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  • Published:
Tumor Biology

Abstract

Metastasis is an important factor in predicting the prognosis of the patients with cancers and contributes to high cancer-related mortality. Recent studies indicated that microRNAs (miRNAs) played a functional role in the initiation and progression of human malignancies. MicroRNAs are small non-coding RNAs of about 22 nucleotides in length that can induce messenger RNA (mRNA) degradation or repress mRNA translation by binding to the 3′ untranslated region (3′-UTR) of their target genes. Overwhelming reports indicated that miRNAs could regulate cancer invasion and metastasis via epithelial-to-mesenchymal transition (EMT)-related and/or non-EMT-related mechanisms. In this review, we concentrate on the underlying mechanisms of miRNAs in regulating cancer progression and metastasis.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (Grant Nos. 81172351 and 81372856) and the Taishan Scholars Programme of Shandong Province (Grant No. ts201511096).

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  1. Department of Pathology, Qilu Hospital, Shandong University, Jinan, China

    Hai-Ting Liu & Peng Gao

  2. Department of Pathology, School of Basic Medicine, Shandong University, Jinan, China

    Hai-Ting Liu & Peng Gao

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Liu, HT., Gao, P. The roles of microRNAs related with progression and metastasis in human cancers. Tumor Biol. 37, 15383–15397 (2016). https://doi.org/10.1007/s13277-016-5436-9

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