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miR-141 targets ZEB2 to suppress HCC progression

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Tumor Biology

Abstract

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. Increasing evidence suggests that microRNAs (miRNAs) are associated with HCC tumorigenesis. The present study was designed to define the role of miR-141 in HCC. The expression of miR-141 was significantly decreased in four HCC cell lines. Overexpression of miR-141 suppressed both the growth and the motility of HCC cells. Furthermore, we identified zinc finger E-box binding homeobox 2 (ZEB2) as a target of miR-141 and miR-141 functioned as a tumor suppressor via ZEB2 targeting in HCC. These data provide a novel potential therapeutic target for HCC treatment.

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Acknowledgments

This work was funded by the Open Research Fund Program of the State Key Laboratory of Virology of China (2013003) and the Natural Science Foundation of Hubei Province (2010CDB08201).

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Authors and Affiliations

  1. State Key Laboratory of Virology, Department of Immunology, Hubei Province Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Wuhan University, Donghu Road 185#, Wuhan, 430071, Hubei Province, China

    Shi-Min Wu, Qin Pan, Feng-Ling Luo & Xiao-Lian Zhang

  2. Department of Clinical laboratory, Wuhan Medical Treatment Center, Wuhan, 430023, China

    Shi-Min Wu, Ding-Yu Zhang & Xiao-Qun Han

  3. Department of Clinical laboratory, Wuhan Medical and Health Center for Women and Children, Wuhan, 430016, China

    Hong-Wu Ai

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  1. Shi-Min Wu
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  2. Hong-Wu Ai
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  3. Ding-Yu Zhang
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  4. Xiao-Qun Han
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  5. Qin Pan
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Correspondence to Xiao-Lian Zhang.

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Shi-Min Wu and Hong-Wu Ai contributed equally to this work.

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Wu, SM., Ai, HW., Zhang, DY. et al. miR-141 targets ZEB2 to suppress HCC progression. Tumor Biol. 35, 9993–9997 (2014). https://doi.org/10.1007/s13277-014-2299-9

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  • DOI: https://doi.org/10.1007/s13277-014-2299-9

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