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Upregulation of MALAT-1 and its association with survival rate and the effect on cell cycle and migration in patients with esophageal squamous cell carcinoma

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Tumor Biology

Abstract

The aim of this study is to investigate whether metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) can be used as a potential therapy target for human esophageal squamous cell carcinoma. MALAT-1 expression levels were detected in 137 paired EC samples and adjacent nonneoplastic tissues. Human esophageal carcinoma cell lines EC9706 and KYSE150 were transfected with MALAT-1 small interference RNA. Cell proliferation, migration/invasion ability, cell cycle, and apoptosis were assessed. MALAT-1 expressed higher levels in esophageal cancer tissues when compared with paired adjacent normal tissues. This high expression was associated with a decreased survival rate. MALAT-1 knockdown induced a decrease in proliferation-enhanced apoptosis, inhibited migration/invasion, and reduced colony formation and led to cell cycle arrest at the G2/M phase. These data indicates that MALAT-1 could be exploited for therapeutic benefit.

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Acknowledgments

We want to acknowledge the evaluators, research assistants, and particularly the adolescents and families who participated in this study.

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Authors and Affiliations

  1. Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, 453100, China

    Wenjian Yao, Ling Guo, Yonglian Wang, Bo Qi, Shangguo Liu, Xiuguang Qin & Baosheng Zhao

  2. Department of Pathology, Xinxiang Medical University, Xinxiang, Henan, 453003, China

    Yu Bai & Yongzhen Li

  3. Department of Nosocomial Infection Administration, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, 453100, China

    Yan Li & Ping Zeng

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  1. Wenjian Yao
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  2. Yu Bai
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  3. Yan Li
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  4. Ling Guo
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Correspondence to Baosheng Zhao.

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Yao, W., Bai, Y., Li, Y. et al. Upregulation of MALAT-1 and its association with survival rate and the effect on cell cycle and migration in patients with esophageal squamous cell carcinoma. Tumor Biol. 37, 4305–4312 (2016). https://doi.org/10.1007/s13277-015-4223-3

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  • DOI: https://doi.org/10.1007/s13277-015-4223-3

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