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Polymorphisms of DNA repair genes XPD, XRCC1, and OGG1, and lung adenocarcinoma susceptibility in Chinese population

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Tumor Biology

Abstract

Lung adenocarcinoma (ADC) is one of the major histological types of lung cancer. Genetic polymorphism in DNA repair genes and lung ADC susceptibility is well documented. In this case–control study, the association between the polymorphic sites of DNA repair genes XPD-751, XRCC1-399, and OGG1-326, and lung ADC susceptibility in ethnic Han Chinese population has been investigated. Genomic DNA was isolated from the peripheral blood of 201 healthy controls and 82 lung ADC patients from the people of Hunan Province, China. Polymorphisms of the investigated genes were analyzed by using polymerase chain reaction–restriction fragment length polymorphism. There was no significant difference between the samples from lung ADC patients and healthy controls about the genotype frequencies of XPD-751, XRCC1-399, and OGG1-326 sites. However, multifactor dimensionality reduction analysis showed that the genetic polymorphisms of the three-loci models of DNA repair genes (XPD-751/XRCC1-399/OGG1-326) are associated with lung ADC. Thus, this study reveals that a three-order interaction among the polymorphic sites of XPD-751, XRCC1-399, and OGG1-326 is associated with lung ADC risk in the studied population, although polymorphism in individual gene was not associated.

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Acknowledgments

The work was supported by the National Basic Research Program of China (grant no. 2011CB910700, branch no. 2011CB910704).

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Authors and Affiliations

  1. Department of Biochemistry, School of Life Sciences, Central South University, Changsha, Hunan, 410013, China

    Fang-dan Ouyang, Fu-lan Yang, Han-chun Chen, Md. Asaduzzaman Khan, Feng-mao Huang, Xin-xing Wan, Ai-hua Xu, Xing Huang, Mei-juan Zhou, Qian Fang & Dian-zheng Zhang

  2. Teaching-Research Office of Biochemistry, Yiyang Medical College, Yiyang, Hunan, 413000, China

    Fang-dan Ouyang

  3. Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China

    Feng-mao Huang

  4. Department of Biochemistry/Molecular Biology and Center for Chronic Disorders of Aging, Philadelphia College of Osteopathic Medicine, Philadelphia, PA, 19131, USA

    Dian-zheng Zhang

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  1. Fang-dan Ouyang
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  2. Fu-lan Yang
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  3. Han-chun Chen
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  4. Md. Asaduzzaman Khan
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Correspondence to Han-chun Chen.

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Fang-dan Ouyang and Fu-lan Yang contributed equally to this work.

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Ouyang, Fd., Yang, Fl., Chen, Hc. et al. Polymorphisms of DNA repair genes XPD, XRCC1, and OGG1, and lung adenocarcinoma susceptibility in Chinese population. Tumor Biol. 34, 2843–2848 (2013). https://doi.org/10.1007/s13277-013-0844-6

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  • DOI: https://doi.org/10.1007/s13277-013-0844-6

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