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Cell-shaped silicon-on-insulator microdosimeters: characterization and response to 239PuBe irradiations

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Abstract

This work tested the feasibility of a silicon-on-insulator microdosimeter, which mimics the size and shape of specific cells within the human body, to determine dose equivalent from neutron irradiation. The microdosimeters were analyzed in terms of their basic diode characteristics, i.e., leakage current as a function of bias voltage. Lineal energy spectra were acquired using two different converter layers placed atop the microdosimeter: a tissue-substitute converter made from high-density polyethylene, and a boron converter consisting of epoxy coated with boron powder. The spectra were then converted into absorbed dose and dose equivalent. Experimental results were compared to Monte Carlo simulations of the neutron irradiations, revealing good agreement. Uncertainty in the dose equivalent determinations was 7.5% when using the cell-shaped microdosimeter with the tissue-substitute converter and 13.1% when using the boron converter. This work confirmed that the SOI approach to cell-mimicking microdosimetry is feasible.

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Funding

This work was supported in part by a research agreement between United States Naval Academy and Louisiana State University: Contract No N00189-13-P-0786.

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Authors and Affiliations

  1. Medical Physics and Health Physics Program, Department of Physics and Astronomy, Louisiana State University, 439 Nicholson Hall, Tower Dr., Baton Rouge, LA, 70803-4001, USA

    Anthony Mazza, Wayne Newhauser, Stephen Pittman, Andrew Halloran & Paul Maggi

  2. Department of Physics, Mary Bird Perkins Cancer Center, Baton Rouge, LA, USA

    Anthony Mazza & Wayne Newhauser

  3. Nanoscale Research Facility, University of Florida, Gainesville, FL, USA

    Brent Gila

  4. Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW, Australia

    Linh Tran & Anatoly Rosenfeld

  5. United States Naval Academy, Annapolis, MD, USA

    James Ziegler

Authors
  1. Anthony Mazza
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  2. Wayne Newhauser
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  3. Stephen Pittman
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  4. Andrew Halloran
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  5. Paul Maggi
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  6. Linh Tran
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  7. Brent Gila
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  8. Anatoly Rosenfeld
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  9. James Ziegler
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Correspondence to Anthony Mazza.

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The authors declare that they have no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Mazza, A., Newhauser, W., Pittman, S. et al. Cell-shaped silicon-on-insulator microdosimeters: characterization and response to 239PuBe irradiations. Australas Phys Eng Sci Med 40, 667–673 (2017). https://doi.org/10.1007/s13246-017-0576-9

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  • DOI: https://doi.org/10.1007/s13246-017-0576-9

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