Abstract
A hierarchical chitosan/polyvinyl alcohol/polyethylene glycol/nonwoven fabric (CS/PVA/PEG/NWF) micro/nanofiber composite membrane (CM) was prepared via electrospinning as a potential wound dressing. The polyester/viscose NWF acting as a substrate to receive the nanofiber layer was modified by alkali deweighting. Meanwhile, PEG with various additive amount was used to afford morphological regulation and control. As a result, the NWF modified with 7.5% NaOH solution exhibited a good hydrophilia and a superior dimensional stability based on smaller elongation at break and higher peel strength. In addition, the morphology of the nanofiber layer was closely related to PEG content. CS/PVA/PEG nanofiber with smaller diameter was spun when PEG content reached to 3.0%. Accordingly, the micro/nanofiber CM showed an opportune water absorption and good air permeability. Furthermore, neither hemolysis nor cytotoxicity phenomena appeared for the resultant CM, since the hemolysis rate and the cell viability were less than 5% and more than 70%, respectively.
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Acknowledgements
This work was financially supported by the Anhui Provincial Natural Science Foundation (Grant Number 2208085QE139), College Student Innovation and Entrepreneurship Training Program (Grant Number S202110363236), the Scientific Research Foundation for Introduction of Talents of Anhui Polytechnic University (Grant Numbers 2020YQQ047, 2020YQQ012), the Joint Open Foundation of Anhui Engineering and Technology Research Center of Textile and Anhui Province College Key Laboratory of Textile Fabrics (Grant Numbers 2021AETKL12, 2021AETKL16).
Funding
Funding was provided by The Scientific Research Foundation for Introduction of Talents of Anhui Polytechnic University, 2020YQQ047, Zhen Wang, the Joint Open Foundation of Anhui Engineering and Technology Research Center of Textile and Anhui Province College Key Laboratory of Textile Fabrics, 2021AETKL12, Zhen Wang, College Student Innovation and Entrepreneurship Training Program, S202110363236, Zhen Wang.
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Sun, Z., Liu, Q., Wang, Z. et al. Hierarchical chitosan/polyvinyl alcohol/polyethylene glycol/nonwoven fabric micro/nanofiber composite membrane: a potential biomaterial for wound dressing. Macromol. Res. 31, 1209–1215 (2023). https://doi.org/10.1007/s13233-023-00204-y
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DOI: https://doi.org/10.1007/s13233-023-00204-y