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Green Synthesis of Metal Oxide Nanoparticles: a Novel Approach to Treat Diabetes Mellitus

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Abstract

Diabetes mellitus is a metabolic disorder in which a person fails to produce adequate insulin or insulin reactions to cells, so that blood sugar levels are high in diabetes patients. Nanoparticles of small particle size have very significant effects against other types of dosage. Diabetes is treated with metal oxide-like nanoparticles such as zinc oxide, silver oxide, cerium oxide, magnesium oxide, vanadium oxide, chromium oxide, and gold nanoparticles. Different plants are used for the green synthesis of zinc, silver, magnesium oxide, cerium oxide, and golden nanoparticles. These analyses include separate in vitro and in vivo tests. The in vitro studies include nanoparticles characterization, antioxidant studies, anti-diabetic studies, and green synthesized nanoparticles phytochemical studies. In the in vivo trials, the animal research involves a range of test models, diabetes induction, experimental design, sample collection, and blood sample characterization by different testing methods. Studies in in vitro and in vivo reveal nanoparticles of metal oxide to be anti-diabetic.

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Acknowledgements

Thanks to the Sinhgad Institute of Pharmacy, Narhe, Pune-41, the authors would like to have the requisite infrastructural research facilities.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmacy, Narhe, Pune, Maharashtra, 411041, India

    Shubhangee Gaikwad & Amol Bansode

  2. Department of Pharmaceutical Quality Assurance, Sinhgad Institute of Pharmacy, Narhe, Pune, Maharashtra, 411041, India

    Shruti Vora, Vishal Garje & Saurabh Bhaiya

  3. School of Pharmacy MAEER’S Maharashtra Institute of Pharmacy, MIT WPU, MIT Campus, Paud Road Kothrud, Pune, Maharashtra, 411041, India

    Shubhangee Gaikwad & Vishnu Choudhari

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All persons who meet authorship criteria are listed as authors, and all authors certify that they have participated sufficiently in the work to take public responsibility for the content, including participation in the concept, design, analysis, writing, or revision of the manuscript. Furthermore, each author certifies that this material or similar material has not been and will not be submitted to or published in any other publication.

Conception and design of study: SG and VC. Acquisition of data: SV. Analysis and/or interpretation of data: AB and SG. Drafting the manuscript: VG and SB. Revising the manuscript critically for important intellectual content: VC, SG, and AB

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Correspondence to Shubhangee Gaikwad.

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Highlights

• The study of nanoparticles of metal oxide (NPs) for diabetes care.

• Green synthesis approach for NPs is harmless, environmentally friendly, and without side effect on the chemical method.

• This review provides information of research analysis of metal oxide nanoparticles alternate treatment for diabetes mellitus.

• Detailed account on practical aspects of metal oxide nanoparticle synthesis and evaluation for diabetic activity.

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Gaikwad, S., Vora, S., Bansode, A. et al. Green Synthesis of Metal Oxide Nanoparticles: a Novel Approach to Treat Diabetes Mellitus. BioNanoSci. 13, 1582–1592 (2023). https://doi.org/10.1007/s12668-023-01205-y

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