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Pain Control by Novel Route of Gifted Choice Against Peroral Route

  • Research Paper
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Journal of Maxillofacial and Oral Surgery Aims and scope Submit manuscript

Abstract

Introduction

Pain after surgical extraction of third molars has been a nemesis for oral surgeons with clinicians, thus striving for an analgesic modality. NSAIDs are among the most widely used therapeutic classes of analgesics. Transbuccal diclofenac sodium patches have been developed as an innovative drug delivery system using buccal mucosa as a gifted choice, hence overcoming first pass metabolism and offering the advantage of sustained drug delivery with reduced incidence of systemic adverse effects.

Aim

A comparative study was conducted to evaluate the efficacy of diclofenac sodium for pain control, administered via the far-fetched and gifted novel route through the transbuccal patch and by ever popular per oral route and also to assess the adverse effects vis-à-vis for transbuccal diclofenac patch and oral diclofenac following extraction of bilaterally symmetrical impacted mandibular third molars under local anaesthesia.

Methodology

Thirty healthy subjects of both the sexes in the age of 12 to 50 years with asymptomatic bilaterally symmetrical mandibular third molars underwent extraction under LA. It is a split-mouth study, i.e. after the extraction of tooth on one side, diclofenac sodium (50 mg) via oral route was given and then in another visit, when the same patient is comfortable and asymptomatic, extraction on contralateral side was executed and transbuccal patched diclofenac sodium (20 mg) was applied. Pain was measured on visual analog scale and verbal rating scale by the patient for 3 days and adverse effects if any were noted.

Result

Statistical analysis showed that transbuccal diclofenac sodium was significantly efficacious when compared to the drug administered orally. Also, statistically significant results were obtained in percentage reduction in pain from 1st to 3rd postoperative day in transbuccal group. No significant difference is seen for adverse reactions.

Conclusion

Transbuccal diclofenac sodium patch is more efficacious and can be used for pain control.

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Abbreviations

TBDP:

Transbuccal diclofenac patch

VAS:

Visual analog scale

VRS:

Verbal rating scale

NSAISs:

Non-steroidal anti-inflammatory drugs

HPMC:

Hydroxypropyl methylcellulose

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Acknowledgements

We would like to show our gratitude to Sudha Rustagi College of Dental Sciences and Research, Faridabad, for sharing its pearls of wisdom with us during the course of this research. We are also immensely grateful to Dr K R Indushekhar, Member secretary, Institutional Ethical Committee, who provided insight and expertise that greatly assisted the study.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, SR College of Dental Sciences and Research, Faridabad, India

    Kartikeya Sharma, Ashish Gupta, Pankaj Bansal & Shivprasad Behera

  2. Department of Conservative Dentistry and Endodontics, Kothiwal Dental College and Research Centre, Moradabad, India

    Pallavi Sharma

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  1. Kartikeya Sharma
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  2. Pallavi Sharma
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  3. Ashish Gupta
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Correspondence to Pallavi Sharma.

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Conflict of interest

Authors Dr. Kartikeya Sharma, Dr. Pallavi Sharma, Dr. Ashish Gupta, Dr. Pankaj Bansal and Dr. Shivprasad Behera declare that they have no conflict of interest.

Ethical Approval

All procedures performed in the study involving human participants were in accordance with the ethical standards approved by the Member Secretary, Institutional Ethical Committee, Sudha Rustagi College of Dental Sciences and Research, Faridabad, affiliated to Pt. B.D. Sharma University of Health and Sciences, Rohtak, which is recognized by the Dental Council of India and Ministry of Health and Family Welfare, Govt. of India.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

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Sharma, K., Sharma, P., Gupta, A. et al. Pain Control by Novel Route of Gifted Choice Against Peroral Route. J. Maxillofac. Oral Surg. 18, 339–344 (2019). https://doi.org/10.1007/s12663-017-1001-3

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  • DOI: https://doi.org/10.1007/s12663-017-1001-3

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