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Tet Enzymes-Mediated DNA 5hmC Modification in Cerebral Ischemic and Hemorrhagic Injury

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Abstract

5-Hydroxymethylcytosine (5hmC) has recently been found that plays an important role in many diseases; however, there are still few studies in the field of stroke. The purpose of this review is to introduce the influence and function of 5hmC in stroke, in order for more people can study it. In this review, we introduced the role of 5hmC in ischemia and hemorrhage stroke, and summarized the possible therapeutic prospects of 5hmC in stroke. In conclusion, we suggest that 5hmC may serve as a biomarker or therapeutic target for the treatment of stroke.

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Funding

This work was supported by grants from the Natural Science Foundation of Jiangsu Higher Education Institution (21KJB310020) and the Priority Academic Program Development of Jiangsu Higher Education Institutions.

Author information

Author notes

  1. Xiaohua Ma and Bo Yang are co-first authors.

Authors and Affiliations

  1. Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215123, China

    Xiaohua Ma & Zhigang Miao

  2. Institute of Neuroscience of Soochow University, 199 Ren-Ai Road, Suzhou, 215123, China

    Xiaohua Ma & Zhigang Miao

  3. Department of Anesthesiology, The Second Affiliated Hospital of Soochow University, Suzhou City, China

    Bo Yang

  4. Gusu School, Suzhou Science & Technology Town Hospital, Nanjing Medical University, Suzhou, 215153, China

    Xiaojing Li

Authors
  1. Xiaohua Ma
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  2. Bo Yang
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  3. Xiaojing Li
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  4. Zhigang Miao
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Contributions

Xiaohua Ma and Bo Yang are responsible for writing and literature review; Xiaojing Li and Zhigang Miao are responsible for the conception and editing of the article.

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Correspondence to Xiaojing Li or Zhigang Miao.

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Ma, X., Yang, B., Li, X. et al. Tet Enzymes-Mediated DNA 5hmC Modification in Cerebral Ischemic and Hemorrhagic Injury. Neurotox Res 40, 884–891 (2022). https://doi.org/10.1007/s12640-022-00505-7

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  • DOI: https://doi.org/10.1007/s12640-022-00505-7

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