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Exercise-induced lowering of chemerin is associated with reduced cardiometabolic risk and glucose-stimulated insulin secretion in older adults

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The journal of nutrition, health & aging

Abstract

Objective: To determine the effect of exercise on chemerin in relation to changes in fat loss, insulin action, and dyslipidemia in older adults. Participants: Thirty older (65.9±0.9yr) obese adults (BMI:34.5±0.7kg/m2). Setting: Single-center, Cleveland Clinic. Design: Prospective clinical trial. Intervention: Twelve-weeks of exercise training (60minutes/day, 5day/week at ∼85% HRmax). Subjects were instructed to maintain habitual nutrient intake. Measurements: Plasma chemerin was analyzed using an enzyme-linked immunosorbent assay. Peripheral and hepatic insulin sensitivity was assessed using a euglycemic-hyperinsulinic clamp with glucose kinetics. First-phase and total glucose-stimulated insulin secretion (GSIS) was calculated from an oral glucose tolerance test. Fasting blood lipids (cholesterol, triglycerides), total/visceral fat (dual-x-ray absorptiometry and computerized tomography) and cardiorespiratory fitness (treadmill test) were also tested pre and post intervention. Results: Exercise increased fitness and reduced total/visceral fat, blood lipids, and firstphase GSIS (P<0.05). Training also increased peripheral insulin sensitivity and lowered basal/insulin-related hepatic glucose production (P<0.01). The intervention reduced chemerin (87.1±6.0 vs. 78.1±5.8ng/ml; P=0.02), and the reduction correlated with decreased visceral fat (r=0.50, P=0.009), total body fat (r=0.42, P=0.02), cholesterol (r=0.38, P=0.04), triglycerides (r=0.36, P=0.05), and first-phase and total GSIS (r=0.39, P=0.03 and r=0.43, P=0.02, respectively). Conclusions: Lower chemerin appears to be an important hormone involved in cardiometabolic risk and GSIS reduction following exercise in older adults.

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Authors and Affiliations

  1. Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA

    S. K. Malin, A. Mulya, H. Huang & John P. Kirwan

  2. Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, 44195, USA

    S. D. Navaneethan

  3. Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA

    S. K. Malin & John P. Kirwan

  4. Metabolic Translational Research Center, Endocrine and Metabolism Institute, Cleveland, Clinic, Cleveland, OH, 44195, USA

    John P. Kirwan

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Malin, S.K., Navaneethan, S.D., Mulya, A. et al. Exercise-induced lowering of chemerin is associated with reduced cardiometabolic risk and glucose-stimulated insulin secretion in older adults. J Nutr Health Aging 18, 608–615 (2014). https://doi.org/10.1007/s12603-014-0459-7

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