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Impacts of a 12-week aerobic, resistance, and combined exercise training on serum FAM19A5, glucose homeostasis, and novel cardiovascular risk factors among adults with obesity

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International Journal of Diabetes in Developing Countries Aims and scope Submit manuscript

Abstract

Objective

To determine the impacts of 12 weeks of aerobic, resistance, or combined training on FAM19A5, glucose homeostasis, body composition, and physical performance in obese men.

Methods

Fifty-eight obese men [age = 49 ± 6 years; body mass index (BMI) = 29 ± 2 kg m−2] were randomly assigned to aerobic training (n = 14), resistance training (n = 15), combined training (n = 15), and control (n = 14) groups. Interventions were three sessions per week for 12 weeks.

Results

FAM19A5 levels remained unaltered in all three intervention groups. However, insulin concentrations, triglyceride, HOMA-IR, VAI, TyG, and fat% declined in all three interventions, whereas VO2max increased. In addition, glucose levels, LAP, body weight, and BMI were reduced in aerobic and combined groups, while systolic blood pressure was reduced in resistance and combined programs. We also observed a significant reduction in low-density lipoprotein following only combined exercises and a significant increase in high-density lipoprotein after only aerobic exercises. There was a significant negative relationship between serum levels of FAM19A5 and HOMA-IR.

Conclusion

This is the first report to assess the influence of exercise interventions on circulating FAM19A5 levels in obese adults. Although FAM19A5 levels remained unchanged in all three interventions, our work provides information to support that aerobic, resistance, and combined regimens can be effective in improving HOMA-IR, triglyceride, systolic blood pressure, BMI, and aerobic performance in obese men. Additional studies with large sample size should be conducted to further clarify the underlying mechanisms.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions.

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Acknowledgment

The authors thank all of the participants for their time and effort in this study.

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Authors and Affiliations

  1. Exercise Physiology Research Center, Lifestyle Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

    Ehsan Mir, Alireza Shamseddini & Behzad Bazgir

  2. Department of Internal Medicine, Vasei Hospital, Sabzevar University of Medical Sciences, Sabzevar, Iran

    Najmeh Rahimi

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  1. Ehsan Mir
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Correspondence to Behzad Bazgir.

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The institutional review board at the Baqiyatallah University of Medical Sciences (Project No. IR.BMSU.BAQ.REC.1400.023) approved the study research protocol, and written informed consent was provided by all participants.

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ClinicalTrials.gov Identifier: IRCT20151026024717N4.

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Mir, E., Shamseddini, A., Rahimi, N. et al. Impacts of a 12-week aerobic, resistance, and combined exercise training on serum FAM19A5, glucose homeostasis, and novel cardiovascular risk factors among adults with obesity. Int J Diabetes Dev Ctries (2024). https://doi.org/10.1007/s13410-024-01315-7

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