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Activity regulation and applications of metal–organic framework-based nanozymes

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Abstract

As a new generation of artificial enzymes, nanozymes show outstanding advantages such as high stability, low cost, and facile synthesis, which endow them with promising applications in biomedical and environmental fields. Among the various reported nanozymes, metal–organic frameworks (MOFs) could mimic the active center of natural enzymes and provide a hydrophobic environment, which makes MOFs attractive alternatives to natural enzymes. Owing to the highly structural diversity and tailorability of MOFs, rational design will contribute to improve the activity of MOF-based nanozymes and promote their potential applications in both biomedical and environmental fields. Therefore, a comprehensive summary of activity regulatory strategies of MOF-based nanozymes is urgently needed. Firstly, we summarized the activity regulatory strategies of MOFs with intrinsic enzyme-like activities via modulation of metal nodes, ligands, structures and morphologies. Then the applications of MOF-based nanozymes in biosensing, hazardous degradation, antibacterial, and cancer therapy were also introduced. Finally, the current challenges and future perspectives were discussed in depth. It is highly expected that this review will provide a better understanding on the rational design of novel high-performance MOF-based nanozymes.

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摘要

纳米酶作为一代新型人工酶, 由于高稳定性、低成本和易于合成等优点, 引起了人们的广泛关注。其中, 金属有机框架结构(metal organic frameworks, MOFs) 具有模拟天然酶活性中心及其周围微环境的结构特点, 有望成为天然酶在实际应用中的潜在替代品和竞争者。因其结构的多样性和可调性, 理性设计MOF基纳米酶将有助于提高其催化活性并拓展应用。因此, 总结MOF基纳米酶的活性调控策略具有重要意义。在本综述中, 我们首先总结了MOF基纳米酶的调控策略包括金属节点、配体和形貌等, 然后介绍了MOF基纳米酶在生物传感、污染物降解以及抗菌和癌症治疗等方面的应用研究进展, 最后对其当前面临的挑战和未来的发展趋势进行探讨。

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Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (Nos. 31901000 and 22022609), the Natural Science Foundation of Jiangsu Higher Education Institutes of China (No. 19KJA610003), the Postdoctoral Science Foundation of Jiangsu Province (No. 2019K152), and the Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions.

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  1. Ge Fang and Shou-Xin Bao have contributed equally to this work.

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  1. State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, 215123, China

    Ge Fang, Shou-Xin Bao, Gen-Xiu Zhou & Cui-Cui Ge

  2. Suzhou Nanomicro Technology Co., Ltd, Suzhou, 215000, China

    Shou-Xin Bao

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Fang, G., Bao, SX., Zhou, GX. et al. Activity regulation and applications of metal–organic framework-based nanozymes. Rare Met. 43, 900–914 (2024). https://doi.org/10.1007/s12598-023-02311-2

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