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Construction of TiO2/silane nanofilm on AZ31 magnesium alloy for controlled degradability and enhanced biocompatibility

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Abstract

A TiO2 nanofilm was prepared on the surface of AZ31 magnesium alloy with controllable thickness through atomic layer deposition (ALD) technique, which can adjust the corrosion behaviors of AZ31 Mg alloy. Compared with the untreated Mg alloys, corrosion current densities (icorr) can decline by 58% in the 200-cycles TiO2-covered Mg alloy and further decline by up to 74% with the thickness of nanofilm up to 63 nm (400 cycles). The subsequent modification with a cross-linked conversion layer of 3-amino-propyltriethoxysilane (APTES) by a dipping method can produce a compact silane coating on TiO2 nanofilm, which can seal pinholes of TiO2 nanofilm and serve as a barrier to further adjust the corrosion behavior of the substrate. The icorr can decline about two orders of magnitude in the TiO2/silane composite coating. Making the adjustable corrosion rate come true, which can be attributed to the precise control on the thickness of metal oxide nanofilm and additional protection from the compact silane coating. In vitro study discloses that the TiO2/silane hybrid coating shows higher expression of alkaline phosphatase (ALP) and can promote cellular adhesion and proliferation with better cytocompatibility than untreated Mg alloy.

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References

  1. Feng HQ, Wang GM, Jin WH, Zhang XM, Huang YF, Gao A, Wu H, Wu GS, Chu PK. Systematic study of inherent antibacterial properties of magnesium-based biomaterials. ACS Appl Mater Interfaces. 2016;8(15):9662.

    Article  Google Scholar 

  2. Wang JL, Wu YH, Li HF, Liu Y, Bai XL, Chau WH, Zheng YF, Qin L. Magnesium alloy based interference screw developed for ACL reconstruction attenuates peri-tunnel bone loss in rabbits. Biomaterials. 2018;157:86.

    Article  Google Scholar 

  3. Wang JL, Wan Y, Ma ZJ, Guo YC, Yang Z, Wang P, Li JP. Glass forming ability and corrosion performance of Mn-doped Mg–Zn–Ca amorphous alloys for biomedical applications. Rare Met. 2018;37(7):579.

    Article  Google Scholar 

  4. Li X, Liu XM, Wu SL, Yeung KWK, Zheng YF, Chu PK. Design of magnesium alloys with controllable degradation for biomedical implants: from bulk to surface. Acta Biomater. 2016;45:2.

    Article  Google Scholar 

  5. Singer F, Schlesak M, Mebert C, Hohn S, Virtanen S. Corrosion properties of polydopamine coatings formed in one-step immersion process on magnesium. ACS Appl Mater Interfaces. 2015;7(48):26758.

    Article  Google Scholar 

  6. Jiang QT, Zhang K, Li XG, Li YJ, Ma ML, Shi GL, Yuan JW. Corrosion behaviors for peak-aged Mg-7Gd-5Y-lNd-0.5Zr alloys with oxide films. Rare Met. 2016;35(10):758.

    Article  Google Scholar 

  7. Kim J, Mousa HM, Park CH, Kim CS. Enhanced corrosion resistance and biocompatibility of AZ31 Mg alloy using PCL/ZnO NPs via electrospinning. Appl Surf Sci. 2017;396:249.

    Article  Google Scholar 

  8. Reinhart RA. Magnesium metabolism a review with special reference to the relationship between intracellular content and serum levels. Arch Intern Med. 1988;148(11):2415.

    Article  Google Scholar 

  9. Peng F, Li H, Wang DH, Tian P, Tian YX, Yuan GY, Xu DM, Liu XY. Enhanced corrosion resistance and biocompatibility of magnesium alloy by Mg–Al-layered double hydroxide. ACS Appl Mater Interfaces. 2016;8(51):35033.

    Article  Google Scholar 

  10. Li X, Weng ZY, Yuan W, Luo XZ, Wong HM, Liu XM, Wu SL, Yeung KWK, Zheng YF, Chu PK. Corrosion resistance of dicalcium phosphate dihydrate/poly(lactic-co-glycolic acid) hybrid coating on AZ31 magnesium alloy. Corros Sci. 2016;102:209.

    Article  Google Scholar 

  11. Wu H, Wu GS, Chu PK. Effects of cerium ion implantation on the corrosion behavior of magnesium in different biological media. Surf Coat Technol. 2016;306:6.

    Article  Google Scholar 

  12. Ding X, Wang XC, Ding KH, Cui SL, Sun YC. Corrosion prevention of sintered Nd–Fe–B magnet by a phosphate chemical conversion treatment. Rare Met. 2015. https://doi.org/10.1007/s12598-015-0533-2.

    Google Scholar 

  13. Wu GS, Zhang XM, Zhao Y, Ibrahim JM, Yuan GY, Chu PK. Plasma modified Mg–Nd–Zn–Zr alloy with enhanced surface corrosion resistance. Corros Sci. 2014;78(1):121.

    Article  Google Scholar 

  14. Zhao YB, Shi LQ, Ji XJ, Li JC, Han ZZ, Li SQ, Zeng RC, Zhang F, Wang ZL. Corrosion resistance and antibacterial properties of polysiloxane modified layer-by-layer assembled self-healing coating on magnesium alloy. Colloid Surf B. 2018;526:43.

    Article  Google Scholar 

  15. Liu XM, Yang QY, Li ZY, Yuan W, Zheng YF, Cui ZD, Yang XJ, Yeung KWK, Wu SL. A combined coating strategy based on atomic layer deposition for enhancement of corrosion resistance of AZ31 magnesium alloy. Appl Surf Sci. 2018;434:1101.

    Article  Google Scholar 

  16. Daubert JS, Hill GT, Gotsch HN, Gremaud AP, Ovental JS, Williams PS, Oldham CJ, Parsons GN. Corrosion protection of copper using Al2O3, TiO2, ZnO, HfO2, and ZrO2 atomic layer deposition. ACS Appl Mater Interfaces. 2017;9(4):4192.

    Article  Google Scholar 

  17. Yang QY, Yuan W, Liu XM, Zheng YF, Cui ZD, Yang XJ, Pan HB, Wu SL. Atomic layer deposited ZrO2 nanofilm on Mg–Sr alloy for enhanced corrosion resistance and biocompatibility. Acta Biomater. 2017;58:515.

    Article  Google Scholar 

  18. Skoog SA, Elam JW, Narayan RJ. Atomic layer deposition: medical and biological applications. Int Mater Rev. 2013;58(2):113.

    Article  Google Scholar 

  19. Yan HM, Liu Y, Pang SJ, Zhang T. Glass formation and properties of Ti-based bulk metallic glasses as potential biomaterials with Nb additions. Rare Met. 2018;37(10):831.

    Article  Google Scholar 

  20. Qiu JC, Li JH, Wang S, Ma BJ, Zhang S, Guo WB, Zhang XD, Tang W, Sang YH, Liu H. TiO2 nanorod array constructed nanotopography for regulation of mesenchymal stem cells fate and the realization of location-committed stem cell differentiation. Small. 2016;12(13):1770.

    Article  Google Scholar 

  21. Kumar N, Chauhan NS, Mittal A, Sharma S. TiO2 and its composites as promising biomaterials: a review. Biometals. 2018;31(2):1.

    Article  Google Scholar 

  22. Chen S, Guan SK, Chen B, Li W, Wang J, Wang LG, Zhu SJ, Hu JH. Corrosion behavior of TiO2 films on Mg–Zn alloy in simulated body fluid. Appl Surf Sci. 2011;257(9):4464.

    Article  Google Scholar 

  23. Hou SS, Zhang RR, Guan SK, Ren CX, Gao JH, Lu QB, Cui XZ. In vitro corrosion behavior of Ti-O film deposited on fluoride-treated Mg–Zn–Y–Nd alloy. Appl Surf Sci. 2012;258(8):3571.

    Article  Google Scholar 

  24. Cui LY, Gao SD, Li PP, Zeng RC, Zhang F, Li SQ, Han EH. Corrosion resistance of a self-healing micro-arc oxidation/polymethyltrimethoxysilane composite coating on magnesium alloy AZ31. Corros Sci. 2017;118:84.

    Article  Google Scholar 

  25. Liu X, Yue ZL, Romeo T, Weber J, Scheuermann T, Moulton S, Wallace G. Biofunctionalized anti-corrosive silane coatings for magnesium alloys. Acta Biomater. 2013;9(10):8671.

    Article  Google Scholar 

  26. Zomorodian A, Brusciotti F, Fernandes A, Carmezim MJ, Moura e Silva T, Fernandes JCS, Montemor MF. Anti-corrosion performance of a new silane coating for corrosion protection of AZ31 magnesium alloy in Hank’s solution. Surf Coat Technol. 2012;206(21):4368.

    Article  Google Scholar 

  27. Dermience M, Lognay G, Mathieu F, Goyens P. Effects of thirty elements on bone metabolism. J Trace Elem Med Biol. 2015;32:86.

    Article  Google Scholar 

  28. Liu J, Zheng B, Wang P, Wang XG, Zhang B, Shi QP, Xi TF, Chen M, Guan S. Enhanced in vitro and in vivo performance of Mg–Zn–Y–Nd alloy achieved with APTES pretreatment for drug-eluting vascular stent application. ACS Appl Mater Interfaces. 2016;8(28):17842.

    Article  Google Scholar 

  29. Trino LD, Dias LFG, Albano LGS, Bronze-Uhle ES, Rangel EC, Graeff CFO, Lisboa-Filho PN. Zinc oxide surface functionalization and related effects on corrosion resistance of titanium implants. Ceram Int. 2018;44(4):4000.

    Article  Google Scholar 

  30. Zhao H, Cai S, Niu SX, Zhang RY, Wu XD, Xu GH, Ding ZT. The influence of alkali pretreatments of AZ31 magnesium alloys on bonding of bioglass–ceramic coatings and corrosion resistance for biomedical applications. Ceram Int. 2015;41(3):4590.

    Article  Google Scholar 

  31. Aarik J, Aidla A, Uustare T, Sammelselg V. Morphology and structure of TiO2 thin films grown by atomic layer deposition. J Cryst Growth. 1995;148(3):268.

    Article  Google Scholar 

  32. Shao PH, Tian JY, Zhao ZW, Shi WX, Gao SS, Cui FY. Amorphous TiO2 doped with carbon for visible light photodegradation of rhodamine B and 4-chlorophenol. Appl Surf Sci. 2015;324(324):35.

    Article  Google Scholar 

  33. Eisenberg D, Ahn HS, Bard AJ. Enhanced photoelectrochemical water oxidation on bismuth vanadate by electrodeposition of amorphous titanium dioxide. J Am Chem Soc. 2014;136(40):14011.

    Article  Google Scholar 

  34. Dong ZB, Ding DY, Li T, Ning CQ. Facile fabrication of Si-doped TiO2 nanotubes photoanode for enhanced photoelectrochemical hydrogen generation. Appl Surf Sci. 2018;436:125.

    Article  Google Scholar 

  35. Su Y, Chen S, Quan X, Zhao HM, Zhang YB. A silicon-doped TiO2 nanotube arrays electrode with enhanced photoelectrocatalytic activity. Appl Surf Sci. 2008;255(5):2167.

    Article  Google Scholar 

  36. Yang W, Zhu ZJ, Wang JJ, Wu YC, Zhai T, Song GL. Slow positron beam study of corrosion behavior of AM60B magnesium alloy in NaCl solution. Corros Sci. 2016;106:271.

    Article  Google Scholar 

  37. Jamesh M, Kumar S, Sankara Narayanan TSN. Corrosion behavior of commercially pure Mg and ZM21 Mg alloy in Ringer’s solution Long term evaluation by EIS. Corros Sci. 2011;53(2):645.

    Article  Google Scholar 

  38. Zeng RC, Cui LY, Jiang K, Liu R, Zhao BD, Zheng YF. In vitro corrosion and cytocompatibility of a microarc oxidation coating and poly(L-lactic acid) composite coating on Mg-1Li-1Ca alloy for orthopedic implants. ACS Appl Mater Interfaces. 2016;8(15):10014.

    Article  Google Scholar 

  39. Gaharwar AK, Mihaila SM, Swami A, Patel A, Sant S, Reis RL, Marques AP, Gomes ME, Khademhosseini A. Bioactive silicate nanoplatelets for osteogenic differentiation of human mesenchymal stem cells. Adv Mater. 2013;25(24):3329.

    Article  Google Scholar 

  40. Zhang YZ, Liu XM, Li ZY, Zhu SL, Yuan XB, Cui ZD, Yang XJ, Chu PK, Wu SL. Nano Ag/ZnO-incorporated hydroxyapatite composite coatings: highly effective infection prevention and excellent osteointegration. ACS Appl Mater Interfaces. 2018;10(1):1266.

    Article  Google Scholar 

  41. Xie D, Wang HH, Ganesan R, Leng YX, Sun H, Huang N. Fatigue durability and corrosion resistance of TiO2 films on CoCrMo alloy under cyclic deformation. Surf Coat Technol. 2015;275:252.

    Article  Google Scholar 

  42. Hartwig A, Klein O, Karl H. Sputtered titanium dioxide thin films for galvanic corrosion protection of AISI 304 stainless steel coupled with carbon fiber reinforced plastics. Thin Solid Films. 2017;621:211.

    Article  Google Scholar 

  43. Umeda J, Nakanishi N, Kondoh K, Imai H. Surface potential analysis on initial galvanic corrosion of Ti/Mg–Al dissimilar material. Mater Chem Phys. 2016;179:5.

    Article  Google Scholar 

  44. Kim J, Gilbert JL. Cytotoxic effect of galvanically coupled magnesium-titanium particles. Acta Biomater. 2016;30:368.

    Article  Google Scholar 

  45. Knez M, Nielsch K, Niinistö L. Synthesis and surface engineering of complex nanostructures by atomic layer deposition. Adv Mater. 2007;19(21):3425.

    Article  Google Scholar 

  46. Ren N, Li JH, Qiu JC, Sang YH, Jiang HD, Boughton RI, Huang L, Huang W, Liu H. Nanostructured titanate with different metal ions on the surface of metallic titanium: a facile approach for regulation of rBMSCs fate on titanium implants. Small. 2014;10(15):3169.

    Article  Google Scholar 

  47. Zhang L, Pei J, Wang HD, Shi YJ, Niu JL, Yuan F, Huang H, Zhang H, Yuan GY. Facile preparation of poly(lactic acid)/brushite bilayer coating on biodegradable magnesium alloys with multiple functionalities for orthopedic application. ACS Appl Mater Interfaces. 2017;9(11):9437.

    Article  Google Scholar 

  48. Jo YK, Choi BH, Kim CS, Cha HJ. Diatom-inspired silica nanostructure coatings with controllable microroughness using an engineered mussel protein glue to accelerate bone growth on titanium-based implants. Adv Mater. 2017;29(46):1704906.

    Article  Google Scholar 

  49. Lipski AM, Pino CJ, Haselton FR, Chen IW, Shastri VP. The effect of silica nanoparticle-modified surfaces on cell morphology, cytoskeletal organization and function. Biomaterials. 2008;29(28):3836.

    Article  Google Scholar 

  50. Han P, Cheng PF, Zhang SX, Zhao CL, Ni JH, Zhang YZ, Zhong WR, Hou P, Zhang XN, Zheng YF, Chai YM. In vitro and in vivo studies on the degradation of high-purity Mg (99.99wt.%) screw with femoral intracondylar fractured rabbit model. Biomaterials. 2015;64:57.

    Article  Google Scholar 

  51. Zainal Abidin NI, Rolfe B, Owen H, Malisano J, Martin D, Hofstetter J, Uggowitzer PJ, Atrens A. The in vivo and in vitro corrosion of high-purity magnesium and magnesium alloys WZ21 and AZ91. Corros Sci. 2013;75(7):354.

    Article  Google Scholar 

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Acknowledgements

This work was financially supported by the Natural Science Fund of Hubei Province (No. 2018CFA064), the National Natural Science Foundation of China (NSFC) (Nos. 51671081 and 51422102), the National Key Research and Development Program of China (No. 2016YFC1100600, sub-project 2016YFC1100604), the Hong Kong Research Grants Council (RGC) General Research Funds (GRF) (Nos. 11301215, 11205617 and 17214516), and RGC/NSFC (N_HKU725-16), the Hong Kong Innovation and Technology Commission (ITC) (Nos. ITS/287/17 and GHX/002/14SZ) and the Health and Medical Research Fund (No. 03142446).

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Authors and Affiliations

  1. School of Materials Science and Engineering, Hubei University, Wuhan, 430062, China

    Lei Huang, Kun Su & Xiang-Mei Liu

  2. State Key Laboratory for Turbulence and Complex System, Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing, 100871, China

    Yu-Feng Zheng

  3. Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, 999077, Hong Kong, China

    Kelvin Wai-Kwok Yeung

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  1. Lei Huang
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Correspondence to Xiang-Mei Liu.

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Huang, L., Su, K., Zheng, YF. et al. Construction of TiO2/silane nanofilm on AZ31 magnesium alloy for controlled degradability and enhanced biocompatibility. Rare Met. 38, 588–600 (2019). https://doi.org/10.1007/s12598-018-1187-7

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